Medication Description: Salazopyridazinum
SALAZOPIRIDAZIN (Salazopyridazinum). 5- (para- [N- (3-Methoxypyridazinyl-6) -sulfamido] -phenylazo) -salicylic acid.
Synonyms: Salazodin, Salazodin.
Crystalline powder orange.
Salazopyridazin is practically insoluble in water, slightly soluble in alcohol, soluble in caustic soda solution.
The structure and nature of the action is close to salazosulfapiridin. It is a product of the azo compounds of sulfapyridazine and salicylic acid. In the body it decomposes into sulfapyridazine and 5-aminosalicylic acid (see Mesalazine), which have an antibacterial and anti-inflammatory effect. Like salazosulfapiridin (sulfalazin) exhibits immunocorrective activity.
Salazopyridazin is more active (acts in smaller doses) than salazosulfapyridin.
Salazopyridazin is used for the treatment of patients with ulcerative colitis, as well as for diseases occurring with autoimmune disorders, including as a basic tool in the treatment of rheumatoid arthritis.
With non-specific ulcerative colitis, salazopyridazin is administered to adults by mouth (after meals) in tablets of 0.5 g 4 times a day for 3 to 4 weeks. If during this period the therapeutic effect is manifested, the daily dose is reduced to 1, O - 1, 5 g (0.5 g 2 - 3 times a day) and continue treatment for another 2 - 3 weeks. In the absence of effect, the drug is stopped. Patients with mild forms of the disease are prescribed the drug at first in a daily dose of 1, 5 g, and in the absence of effect they increase the dose to 2 g per day.
Salazopyridazin is prescribed to children aged 3 to 5 years old starting with a dose of 0.5 g per day (2 to 3 doses). In the absence of effect for 2 weeks. the drug is canceled, and if there is a therapeutic effect, the treatment is continued at this dose for 5-7 days, then the dose is reduced by 2 times and the treatment is continued for another 2 weeks. In the case of clinical remission, the daily dose is again halved and prescribed until the 40th-50th day, counting from the start of treatment.
Children between the ages of 5 and 7 are prescribed the drug from 0.75–1.0 g per day, from 7 to 15 years - from a dose of 1, O — 1, 2–1, 5 g per day. Treatment and dose reduction is carried out according to the same scheme as in children from 3 to 5 years.
The use of salazopyridazin combined with the general methods of treatment and diet, recommended for nonspecific ulcerative colitis.
Salazopyridazin can also be used in non-specific ulcerative colitis and Crohn's disease rectally in the form of a suspension and suppositories.
Suspension of salazopyridazin 5% (Suspensio Salazopyridazini 5%). Contains salazopyridazin, tween-80, benzyl alcohol and polyvinyl alcohol. The drug, after agitation, is a slurry of orange color, which then settles.
Used for rectal administration (lesion of the rectum and sigmoid colon, in the preoperative period and after subtotal colectomy, with poor tolerability of the drug in the form of tablets). The suspension is slightly heated and injected in the form of an enema into the rectum or into the stump of the intestine at 20 - 40 ml 1 - 2 times a day.