Description of the medicine: Salazopyridazine (Salazopyridazinum)
Salazopyridazine (Salazopyridazinum). 5- (para- [N - (3-Methoxypyridazinyl-6) sulfamido] phenylazo) salicylic acid.
Synonyms: Salazodin, Salazodin.
Fine-crystalline powder of orange color.
Salazopyridazine is practically insoluble in water, slightly soluble in alcohol, soluble in sodium hydroxide solution.
The structure and nature of the action is close to salazosulfapyridine. It is a product of the azo compound of sulfapyridazine and salicylic acid. In an organism breaks down on sulfapyridazine and 5-aminosalicylic acid (see. Mesalazine), which have antibacterial and anti-inflammatory effects. Like salazosulfapyridine (sulfalazine) exhibits immunocorrective activity.
Salazopyridazine is more active (acts in lower doses) than salazosulfapyridine.
Salazopyridazine is used to treat patients with ulcerative colitis, as well as for diseases that occur with autoimmune disorders, including as a basic tool in the treatment of rheumatoid arthritis.
With ulcerative colitis, salazopyridazine is prescribed to adults inside (after eating) in tablets of 0.5 g 4 times a day for 3 to 4 weeks. If during this period a therapeutic effect is manifested, the daily dose is reduced to 1, O - 1, 5 g (0.5 g 2 - 3 times a day) and continue treatment for another 2 to 3 weeks. In the absence of effect, the drug is stopped. Patients with mild forms of the disease are prescribed the drug first in a daily dose of 1, 5 g, and in the absence of effect, increase the dose to 2 g per day.
For children aged 3 to 5 years, salazopyridazine is prescribed starting with a dose of 0.5 g per day (2 to 3 doses). In the absence of effect for 2 weeks. the drug is canceled, and if there is a therapeutic effect, treatment is continued at this dose for 5 to 7 days, then the dose is reduced by 2 times and treatment is continued for another 2 weeks. In the case of clinical remission, the daily dose is again halved and prescribed up to the 40-50th day, counting from the start of treatment.
For children aged 5 to 7 years, a drug is prescribed starting from 0.75-1, 0 g per day, from 7 to 15 years - with a dose of 1, O - 1, 2 - 1, 5 g per day. Treatment and dose reduction is carried out according to the same scheme as in children from 3 to 5 years.
The use of salazopyridazine is combined with general methods of treatment and diet, recommended for ulcerative colitis.
Salazopyridazine can also be used for ulcerative colitis and Crohn's disease rectally in the form of a suspension and suppositories.
Suspensio Salazopyridazine 5% (Suspensio Salazopyridazini 5%). Contains salazopyridazine, tween-80, benzyl alcohol and polyvinyl alcohol. The drug after shaking is a suspension of orange color, which then settles.
Used for rectal administration (damage to the rectum and sigmoid colon, in the preoperative period and after subtotal colectomy, with poor tolerance of the drug in the form of tablets). The suspension is slightly warmed up and injected as an enema into the rectum or into the stump of the intestine, 20-40 ml 1-2 times a day.