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Medication Description: Nitroxolin (Nitroxolinum)

NITROXOLINE (Nitroxolinum). 5-Nitro-8-hydroxyquinoline.

Synonyms: 5-NOK (from the first letters of the chemical name of the compound "5-nitro - 8 - oxyquinol"), 5-NOK, Nibiol, Nikinol, Nikopet, Nitroxoline, Niuron, Noxibiol, Noxin, Uritrol, etc.

Crystalline powder yellow-green color. Practically insoluble in water.

It has an antibacterial effect on gram-positive and gram-negative bacteria; also effective against some fungi (genus Candida, etc.).

Unlike other 8-hydroxyquinoline derivatives, 5-NOC is rapidly absorbed from the gastrointestinal tract and is excreted unchanged by the kidneys, and therefore there is a high concentration of the drug in the urine.

Applied with infections of the urinary tract (pyelonephritis, cystitis, urethritis, prostatitis, etc.), for the prevention of infections after kidney and urinary tract operations, as well as other diseases caused by microorganisms that are susceptible to this drug. It is often effective when microflora is resistant to other antibacterial agents.

Assign inside. The average daily intake for adults is 0.4 g (0.1 g 4 times a day). The duration of treatment depends on the nature and severity of the disease. In most cases, the treatment course is 2-3 weeks. If necessary, repeat courses with a two-week break. In severe cases, the daily dose is increased to 0.15 - 0.2 g 4 times a day.

The highest daily intake for adults 0.8 g.

The average daily dose for children older than 5 years of 0.2-0.4 g (0.05-0.1 g 4 times a day), younger than 5 years - 0.2 g per day.

Duration of treatment is 2-3 weeks. In chronic urinary tract infections, the drug can be prescribed again for 2 weeks with a 2-week break.

For the prevention of infections in operations on the kidneys and urinary tract, 0.1 g is prescribed per reception 4 times a day for 2 to 3 weeks.

The drug is usually well tolerated. Sometimes there is dyspeptic symptoms (nausea), so it is recommended to take it with meals. Allergic rash is possible.

In case of renal failure, caution should be exercised due to the possible cumulation of the drug.

Urine in the treatment of the drug is painted in saffron yellow color.

In case of hypersensitivity to 8-hydroxyquinoline derivatives, the drug is contraindicated.

Release form: tablets; coated orange, 0.05 g (50 mg) in a package of 50 pieces.

Storage: List B. In a dry, dark place.