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Description of the medicine: Nitroxolin (Nitroxolinum)

NITROXOLINE (Nitroxolinum). 5-nitro-8-hydroxyquinoline.

Synonyms: 5-NOK (from the first letters of the chemical name of the compound "5-nitro - 8 - hydroxyquinol"), 5-NOK, Nibiol, Nikinol, Nikopet, Nitroxoline, Niuron, Noxibiol, Noxin, Uritrol, etc.

Fine crystalline powder of yellow-green color. It is practically insoluble in water.

It has an antibacterial effect on gram-positive and gram-negative bacteria; effective against certain fungi (genus Candida, etc.).

Unlike other derivatives of 8-hydroxyquinoline, 5-NOC is rapidly absorbed from the gastrointestinal tract and excreted unchanged by the kidneys, in connection with which there is a high concentration of the drug in the urine.

Used for infections of the genitourinary tract (pyelonephritis, cystitis, urethritis, prostatitis, etc.), for the prevention of infections after surgery on the kidneys and urinary tract, as well as other diseases caused by microorganisms sensitive to this drug. Often effective in the resistance of microflora to other antibacterial agents.

Assign inside. The average daily dose for adults is 0.4 g (0.1 g 4 times a day). The duration of treatment depends on the nature and severity of the disease. In most cases, the course of treatment is 2-3 weeks. If necessary, repeat courses with a two-week break. In severe cases, the daily dose is increased to 0.15 - 0.2 g 4 times a day.

The highest daily dose for adults is 0.8 g.

The average daily dose for children over 5 years old is 0.2-0.4 g (0.05-0.1 g 4 times a day), younger than 5 years old - 0.2 g per day.

The duration of treatment is 2-3 weeks. In chronic urinary tract infections, the drug can be prescribed again for 2 weeks with a 2-week break.

For the prevention of infections in operations on the kidneys and urinary tract, 0.1 g is prescribed per dose 4 times a day for 2 to 3 weeks.

The drug is usually well tolerated. Dyspeptic symptoms (nausea) are sometimes noted, so it is recommended to take it with meals. Allergic rash is possible.

In renal failure, caution should be exercised because of the possible cumulation of the drug.

Urine during treatment with the drug is painted in saffron yellow.

With increased sensitivity to derivatives of 8-hydroxyquinoline, the drug is contraindicated.

Release form: tablets; coated with an orange color, 0.05 g (50 mg) in a package of 50 pieces.

Storage: List B. In a dry, dark place.