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Description of the medicine: Nalidixic acid (Acidum nalidixicum)

NALIDIC ACID (Acidum nalidixicum). 1-Ethyl-7-methyl-4-one-1, 8-naphthyridine-3-carboxylic acid.

Synonyms: Neigramon, Negram (Brand name "Negram" from the word "gram-negative"), Cistidix, Nagram, Nalidin, Nalidixanum, Nalidixic acid, Nalidixin, Naligram, Nalix, Nalurin, Naxuril, Negram, Nevigramon, Nifinric, Spec , Urogram, Uroneg, Wintomylon, etc.

The crystalline powder is light yellow in color. Insoluble in water.

It is a synthetic antibacterial drug. Effective for infections caused by gram-negative bacteria, intestinal, dysenteric and typhoid bacilli, Proteus, Klebsiella bacillus (Friedlander). It is bacteriostatic and bactericidal. Effective against strains resistant to antibiotics and sulfonamides. It is ineffective against gram-positive cocci (staphylococci, streptococci, pneumococci) and pathogenic anaerobes.

The drug is well absorbed from the gastrointestinal tract. About 80% is excreted in the urine unchanged. The half-life is approximately 8 hours, however, with renal failure reaches 20 hours or more.

It is mainly used for urinary tract infections (cystitis, pyelitis, pyelonephritis) caused by microorganisms sensitive to the drug; most effective in acute infections. It is also prescribed for the prevention of infections in operations on the kidneys and bladder. It is recommended for enterocolitis, cholecystitis, middle ear inflammation and other diseases caused by microorganisms sensitive to the drug, including those resistant to other antibacterial agents.

Adults take 0.5 g orally (1 capsule or 1 tablet), and for more severe infections, 1 g 4 times a day. The course of treatment is at least 7 days. With prolonged treatment, 0.5 g is used 4 times a day.

Children are prescribed at a rate of 60 mg / kg, distributing the daily dose into 4 equal parts.

Usually nalidixic acid is well tolerated; however, nausea, vomiting, diarrhea, headache, dizziness are possible. Allergic reactions (dermatitis, fever, eosinophilia) may occur, as well as increased sensitivity of the skin to sunlight (photodermatosis).

In patients with cerebrovascular accident, parkinsonism, epilepsy, convulsions may occur. In connection with the possibility of convulsive reactions, one should beware of drug overdose in children. Severe adverse reactions require temporary or complete discontinuation of the drug.

Contraindications violation of the liver, depression of the respiratory center. Great caution is necessary in case of insufficient renal function. You can not appoint women in the first 3 months of pregnancy and children under 2 years.

The drug should not be used simultaneously with nitrofurans, since this reduces the antibacterial effect.

Release form: in capsules or tablets on 0,5 g.

Storage: List B.