Description of the medicine: Ciprofloxacin (Ciprofloxacinum; Ciprofloxacine)

Ciprofloxacin (Ciprofloxacinum; Ciprofloxacine). 1. Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo- (1-piperazinyl) -3-quinolinecarboxylic acid.

Produced in the form of hydrochloride and lactate.

Synonyms: Quintor, Cipro, Ciprobai, Arflox, Ciplox, Ciprinol, Cipro, Ciprobay, Ciprobid, Ciproran, Ciproxin, Quintor, etc.

The chemical structure is closest to norfloxacin, from which it differs by replacing the ethyl group at the nitrogen atom in position 1 of the quinoline nucleus with a cyclopropyl radical.

According to the antibacterial spectrum of action, ciprofloxacin is basically similar to other fluoroquinolones, but it has a relatively high activity; Approximately 3 to 8 times more active than norfloxacin.

The drug is effective when administered orally and parenterally. When ingestion, especially on an empty stomach, it is well absorbed. The peak in plasma concentration is observed 1 to 2 hours after ingestion and 30 minutes after intravenous administration. The half-life is about 4 hours. It is not highly bound by plasma proteins. It penetrates well into organs and tissues, passes through the blood-brain barrier. About 40% is excreted in urine unchanged for 24 hours.

Indications for use are basically the same as for ofloxacin, pefloxacin and other fluoroquinolones (respiratory tract infection, skin and soft tissue, bones and joints, gastrointestinal tract, including infections caused by salmonella, shigella, campylobacteria and other pathogens Gonococcal infections, meningitis, postoperative infectious complications, sepsis and other purulent-inflammatory processes).

The drug is highly effective for infections of the urinary tract, when ingested, it quickly penetrates into the kidneys, persists for a long time, has a bactericidal effect on Pseudomonas aeruginosa (the dominant pathogen in complicated urinary tract infections).

The drug is indicated in the treatment of infections in cancer patients.

Assign ciprofloxacin to adults for uncomplicated urinary tract infections by 0.125-0.5 g 2 times a day, with complicated infections of the urinary tract and respiratory tract infections - 0.25-0.5 g 2 times a day; In more severe cases - up to 0.75 g 2 times a day (if parenteral treatment is not performed). The course of treatment is usually 5 to 15 days.

For particularly serious infectious diseases and the inability to take tablets inside, begin with intravenous administration of the drug, preferably in the form of a short-term infusion (about 30 minutes). The ready solution (in vials) can be administered without dilution or diluted in isotonic sodium chloride solution or 5% glucose solution. Concentrate of the infusion solution (in ampoules of 10 ml of a 1% solution) must be diluted before administration.

In acute gonorrhea and uncomplicated cystitis, women are prescribed ciprofloxacin inside a single dose of 0.25 g and intravenously at a dose of 0.1 g.

Doses for intravenous administration in uncomplicated urinary tract infections of 0.1 g 2 times a day, in other cases - 0.2 g 2 times a day. If the patient's condition improves, they switch to taking the drug inside.