Description of the drug: Furagin soluble (Furaginum solubile)

FURAGINUM SOLUBILE.

N- (5-Nitrofuryl-2) -allylideneaminohydantoin, potassium salt.

Synonyms: Solafur, Furagina potassium salt, Furamag, Furaginum-Kalium, Furamag, Solafur.

It is available as a mixture containing 10% furagin soluble and 90% sodium chloride (Furaginum solubile 10% cum Natrio chloridio 90%).

By antibacterial activity is similar to furaginom. The best solubility in comparison with furaginom, allows furagin soluble to be administered intravenously and quickly create a high concentration of the drug in the blood.

Assign adults with severe infectious and inflammatory diseases caused by staphylococcus, streptococcus and other pathogens sensitive to the drug (sepsis, wound and purulent infection, severe burns, acute and chronic cystitis, urethritis, pyelonephritis, prostatitis, cholecystitis, bronchitis, pneumonia, bronchiectasis, Including those complicated by infectious-allergic bronchial asthma, inflammatory diseases of female genital organs, anaerobic infection).

Furagin soluble in capsules is also used to prevent infections during urological operations, cystoscopy, catheterization, etc.

Apply furagin soluble inside, intravenously, intratracheally, intrabronhially, injected also into the cavity and applied topically.

Intravenous 1% solution is administered dropwise slowly for 3 to 4 hours. Daily dose for an adult from 300 to 500 ml of solution, depending on the severity of the disease. The course of treatment consists of 3 - 7 infusions.

When carrying out therapeutic or therapeutic and diagnostic sanation of the bronchi, from 100 to 300 ml of a 1% solution of the drug are intratracheally administered. The course of treatment 3 - 14 infusions. Intrabronhial with bronhofibroskopii inject 0.5 - 1% solution fugagina soluble, heated to 36 - 39 C, fractionally 20 - 60 ml, and when washing the bronchus - heated to 36 - 39 C 0.5% solution, fractionally 50 - 100 Ml in a total dose of 500-800 ml with simultaneous suction of the injected liquid. If necessary, rinse again.

When treating purulent-inflammatory processes (peritonitis, pleural empyema, suppuration of the joint cavities), the cavities are washed with 1% solution.

Locally, the drug is used as a 1% solution in the treatment of burn wounds.

To prepare 0.5% and 1% solutions, 0.5 g or 1 g of the preparation, respectively, is dissolved in 100 ml of hot water for injection and filtered through a millipore filter of no more than 0.45 μm (or through antibacterial ceramic candles or antibacterial glass filters ) Followed by sterilization at 100 ° C for 30 minutes.

Inside take furagin soluble in the form of capsules (after eating) to 0,05 - 0,1 g 3 times a day. The course of treatment is 7-10 days. If necessary, after a 10 - 15-day break, repeat the course.

Possible side effects are the same as when using other nitrofurans.

With rapid intravenous administration of the drug in some cases, headache, nausea, and tinnitus are possible. To prevent these phenomena, simultaneous use of antihistamines is recommended.