Description of the medicine: Protionamide (Protionamidum)
Thioamide a-propylisonicotinic acid, or 2-propyl-thiocarbamoyl-4-ciridine.
Synonyms: Treventix, Prothionamide, Protionamide, 1321 TH, Teraplix, Treventix, Trevintix.
Chemically close to ethionamide, differs only in the replacement of the ethyl radical (C 2 H 5) in position 2 by propyl (CzH).
In terms of anti-tuberculosis activity, it does not differ significantly from ethionamide, but it is better tolerated.
It can be used in combination with isoniazid, pyrazinamide, cycloserine and other anti-TB drugs.
The drug is recommended for poor tolerance of ethionamide, however, due to cross-resistance, it should not be prescribed for the development of tuberculosis resistance to ethionamide in mycobacteria.
Take orally after a meal. Adults are given 0.25 g 3 times a day; with good tolerance - 0.5 g 2 times a day (1 g per day). In patients older than 60 years and with a body weight of less than 50 kg, the daily dose should not exceed 0.75 (most often 0.25 g 2 times a day). Children are prescribed at a rate of 10 to 20 mg / kg per day.
When using the drug, gastrointestinal upsets, skin reactions, dizziness, tachycardia, weakness, paresthesias are possible, but side effects are less pronounced than with ethionamide.
The drug should not be prescribed during pregnancy.
Release form: tablets (dragees) on 0,25 g.
Storage: List B.