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Description of the medicine: Protionamid (Protionamidum)

PROTOONAMIDE (Protionamidum).

The aioamide of a-propyl isonicotinic acid, or 2-propyl-thiocarbamoyl-4-cyridine.

Synonyms: Treventix, Prothionamide, Protionamide, 1321 TH, Teraplix, Treventix, Trevintix.

Chemically close to the ethionamide, differs only by replacing the ethyl radical (C 2 H 5) in position 2 with propyl (CsH).

For antituberculous activity, it does not differ significantly from ethionamide, but is better tolerated.

Can be used in combination with isoniazid, pyrazinamide, cycloserine and other anti-tuberculosis drugs.

The drug is recommended for poor transferability of ethionamide, but due to cross-resistance, it should not be prescribed when developing in mycobacteria tuberculosis resistance to ethionamide.

Is taken orally after a meal. Adults give 0.25 g 3 times a day; With good tolerance - 0.5 g 2 times a day (1 g per day). In patients older than 60 years and with a body weight of less than 50 kg, the daily dose should not exceed 0.75 (most often 0.25 g 2 times a day). Children are prescribed at a rate of 10 - 20 mg / kg per day.

When the drug is used, gastrointestinal disorders, skin reactions, dizziness, tachycardia, weakness, paresthesia, but side effects are less pronounced than with the use of ethionamide.

The drug should not be administered during pregnancy.

Form release: tablets (pills) to 0.25 g.

Storage: List B.