Medication Description: Streptomycin Sulfate (Streptomycini sulfas)
STREPTOMYCINE SULFATE (Streptomycini sulfas).
Streptomycin is an antibiotic that forms during the vital activity of radiant fungi of Streptomyces globisporus streptomycini or other related microorganisms.
Organic base: N-methyl-a-L-glucosamido-b -2-streptosezidostreptidin.
Synonyms: Ampistrep, Diplostrep, Endostrep, Strepsulfat, Streptolin, Strepsulfat, Streptomycine sulfate, Streptaquaine, Strycin, Strysolin, etc.
Available in the form of sulfate.
Streptomycin sulfate is a powder or porous mass of white or almost white color, odorless, bitter taste; hygroscopic. Easily soluble in water, practically insoluble in alcohol, chloroform and ether. It is stable in a weakly acidic environment, but is easily destroyed in solutions of strong acids and alkalis when heated.
Doses are calculated in terms of weight or in units of action (ED); 1 U is equal to 1 μg of chemically pure streptomycin base.
Streptomycin sulfate has a broad spectrum of antimicrobial action. The antibiotic is active against Mycobacterium tuberculosis, as well as most Gram-negative ones (E. coli, Friedlander wand, Influenza wand, causative agents of plague, tularemia, brucellosis and some gram-positive (staphylococcal) microorganisms; less active in relation to streptococci, Pneumococci, staphylococcus, microorganisms; less active in relation to streptococci, pneumococcal bacteria, staphylococci); viruses.
Streptomycin is bactericidal. The effect is associated with the suppression of protein synthesis at the level of ribosomes in the microbial cell.
When ingested, streptomycin is poorly absorbed and is almost completely excreted through the intestines. When administered intramuscularly absorbed well. The maximum concentration in the blood plasma is observed after 1-2 hours. After a single administration of a therapeutic dose, it is retained in the blood for 6 to 8 hours. It is eliminated from the body mainly by the kidneys. With normal excretory function of the kidneys, the body does not accumulate with repeated administration. However, if the kidney function is impaired, the secretion slows down, the concentration in the body increases, and side (neurotoxic) phenomena may develop.
Streptomycin sulfate is used as the main anti-tuberculosis drug for the treatment of mainly newly diagnosed pulmonary tuberculosis and tuberculous lesions of other organs. Previously treated patients, it is advisable to prescribe the drug after laboratory determination of the sensitivity of the mycobacteria secreted to it to patients.
Streptomycin sulfate is also prescribed for inflammatory processes of various localization caused by gram-positive and gram-negative microorganisms sensitive to the drug: for pneumonia caused by Klebsiella (in combination with chloramphenicol), for plague and tularemia (in combination with tetracycline), brucellosis and endocarcinoma and endocarcinoma and endocarcinoma, in case of plague and tularemia (in combination with tetracycline), brucellosis and endocarcinoma, and plague and tularemia (in combination with tetracycline). combination with other antibiotics).
Streptomycin sulfate is used intramuscularly, as well as in the form of aerosols, intratracheal, intracavernous (in adults).