Description medications: Streptomycin sulfate (Streptomycini sulfas)

Streptomycin sulfate (Streptomycini sulfas).

Streptomycin - an antibiotic formed during the life of radiant fungus Streptomyces globisporus streptomycini or other related microorganisms.

The organic base: N-methyl-a -L- glyukozamido- b -2-streptozidostreptidin.

Synonyms: Ampistrep, Diplostrep, Endostrep, Strepsulfat , Streptolin, Strepsulfat, Streptomycine sulfate, Streptaquaine, Strycin, Strysolin and others.

Available in the form of sulfate.

Streptomycin sulfate - powder or porous mass of white or almost white, odorless, bitter taste; hygroscopic. Easily soluble in water, practically insoluble in alcohol, chloroform and ether. Stable in mildly acidic medium, but easily destroyed in acid solutions and strong alkalis under heating.

Doses calculated in terms of weight, or in units of (ED); 1 U equals 1 g of chemically pure streptomycin base.

Streptomycin sulfate has a broad spectrum of antimicrobial action. The antibiotic active against Mycobacterium tuberculosis, as well as most Gram-negative (Escherichia coli, wand Friedlander, wand influenza, agents of plague, tularemia, brucellosis, and some gramopolozhitelnyh (staphylococci) microorganisms. Less active against streptococci, pneumococci not act on anaerobes, rickettsia and viruses.

Effective bactericidal streptomycin. Effect associated with inhibition of protein synthesis at the ribosome level in the microbial cell.

When administered Streptomycin is poorly absorbed and almost completely eliminated through the intestines. If intramuscular administration is well absorbed. The maximum plasma concentration observed after 1-2 hours after a single administration of a therapeutic dose remains in the blood for 6 -.. 8 hours is derived from the body mainly by the kidneys. In normal renal excretory function in the body is not accumulated upon repeated administration. However, if the kidney function, excretion slows down, the concentration in the body increases and may develop side (neurotoxic) effects.

Streptomycin sulfate is used as the main anti-TB drug for the treatment of mainly newly diagnosed pulmonary tuberculosis and tuberculous lesions of other organs. Previously untreated patients, the drug is appropriate to prescribe after laboratory susceptibility to it allocated patients mycobacteria.

Assign also streptomycin sulfate in chronic inflammatory processes of various localization caused by Gram-positive and Gram-negative microorganisms sensitive to the drug: pneumonia caused by Klebsiella (in combination with chloramphenicol), in plague and tularemia (in combination with tetracycline), brucellosis, and endocarditis (in combination with other antibiotics).

Applied streptomycin sulfate injection, as well as aerosols, intratracheally vnutrikavernozno (adults).