Description of the medicine: Streptomycin sulfate (Streptomycini sulfas)
Streptomycin Sulfate (Streptomycini sulfas).
Streptomycin is an antibiotic that is formed during the life of radiant fungi Streptomyces globisporus streptomycini or other related microorganisms.
Organic base: N-methyl-a-L-glucosamido-b -2-streptosidostreptidine.
Synonyms: Ampistrep, Diplostrep, Endostrep, Strepsulfat, Streptolin, Strepsulfat, Streptomycine sulfate, Streptaquaine, Strycin, Strysolin, etc.
Available in the form of sulfate.
Streptomycin sulfate - powder or porous mass of white or almost white, odorless, bitter taste; hygroscopic. Easily soluble in water, practically insoluble in alcohol, chloroform and ether. Stable in a slightly acidic environment, but easily destroyed in solutions of strong acids and alkalis when heated.
Doses are calculated in terms of weight or in units of action (ED); 1 unit is equal to 1 μg of chemically pure streptomycin base.
Streptomycin sulfate has a wide spectrum of antimicrobial activity. The antibiotic is active against Mycobacterium tuberculosis, as well as most gram-negative (Escherichia coli, Friedlander's bacillus, Influenza bacillus, plague, tularemia, brucellosis and some gram-positive (staphylococci) microorganisms; less active against streptococci, pneumococci. Does not affect ankara viruses.
Streptomycin is bactericidal. The effect is associated with the suppression of protein synthesis at the level of ribosomes in a microbial cell.
When administered, streptomycin is poorly absorbed and is almost completely excreted through the intestines. When administered intramuscularly, it is absorbed well. The maximum concentration in blood plasma is observed after 1-2 hours. After a single administration of a therapeutic dose, it remains in the blood for 6 to 8 hours. It is excreted mainly from the body by the kidneys. With normal excretory function of the kidneys, the body does not accumulate with repeated administration. However, in case of impaired renal function, excretion slows down, the concentration in the body rises and side effects (neurotoxic) can develop.
Streptomycin sulfate is used as the main anti-tuberculosis drug for the treatment of mainly newly diagnosed pulmonary tuberculosis and tuberculosis lesions of other organs. For previously treated patients, it is advisable to prescribe the drug after laboratory determination of the sensitivity of mycobacteria secreted to it by patients.
Streptomycin sulfate is also prescribed for purulent-inflammatory processes of various localization caused by gram-positive and gram-negative microorganisms sensitive to the drug: with pneumonia caused by Klebsiella (in combination with chloramphenicol), with plague and tularemia (in combination with tetracycline), brucellosis (and endocardium combination with other antibiotics).
Apply streptomycin sulfate intramuscularly, as well as in the form of aerosols, intratracheally, intracavernosally (in adults).