Medication Description: Pasomycin (Pasomicinum)
Dihydrostreptomycin para-aminosalicylate. Salt PASK (3 mol) and dihydrostreptomycin (1 mol).
Synonyms: Dihydrostreptomycin-Pasquat, Streptopas.
Powder or porous mass of white or yellowish, bitter taste. Easily soluble in water, practically insoluble in alcohol. Easily destroyed in solutions of acids and alkalis and under the action of light.
Applied with various forms of tuberculosis, nonspecific pneumonia, purulent processes caused by bacteria susceptible to streptomycin, as well as in the preoperative period, especially in individuals with a history of tuberculosis. If necessary, passomycin can be combined with other antibacterial drugs.
The resistance of microorganisms to pasomicin develops more slowly than to streptomycin and PAS.
Used intramuscularly. Dose for adults 1 g per day once. In case of poor tolerance of intramuscular injections, 0.5 g per day is administered with the additional intake of PASK (6 g) orally.
Children up to 1 year old appoint 0.1 g, from 1 year to 3 years - 0.2 - 0.25 g, from 3 to 7 years - 0.25 - 0.3 g, from 7 to 12 years - 0.3 - 0.5 g per day.
Pasomicin solution can also be administered in the fistulous passages and pleural cavity (0.25 - 0.5 g).
Passomitsin is dissolved in 2 - 3 ml of a 0.25 - 0.5% solution of novocaine, an isotonic solution of sodium chloride or sterile water for injection. It is necessary to use a freshly prepared solution.
With prolonged use of the drug, disorders of the vestibular apparatus and a decrease in hearing acuity, pruritus, dermatitis, dizziness, and nausea are possible. Care must be taken when prescribing pasomycin in acute and chronic nephritis (due to a possible delay in drug release) and inflammation of the auditory nerve. It is not allowed to administer pasomycin simultaneously with kanamycin, florimitsin, monomitsin and other antibiotics with otoi nephrotoxicity.
Product form: in hermetically sealed vials of 0.5 and 1 g (500 000 and 1 000 000 IU) per dihydrostreptomycin base (with the application of the solvent - 0.5% solution of novocaine in ampoules).
Storage: List B. In a dry, dark place.