Description of the medicine: Pasomycin (Pasomicinum)
Dihydrostreptomycin para-aminosalicylate. Salt PASK (3 mol) and dihydrostreptomycin (1 mol).
Synonyms: Dihydrostreptomycin Pascate, Streptopas.
Powder or porous mass of white or yellowish color, bitter taste. Easily soluble in water, practically insoluble in alcohol. It is easily destroyed in solutions of acids and alkalis and under the influence of light.
It is used for various forms of tuberculosis, non-specific pneumonia, purulent processes caused by bacteria sensitive to streptomycin, as well as in the preoperative period, especially in people with a history of tuberculosis diseases. If necessary, pasomycin can be combined with other antibacterial drugs.
Resistance of microorganisms to pasomycin develops more slowly than to streptomycin and PASK.
Apply intramuscularly. Dose for adults 1 g per day once. With poor tolerance of intramuscular injections, 0.5 g per day is administered with an additional intake of PASK (6 g) inside.
Children under 1 year are prescribed 0.1 g, from 1 year to 3 years - 0.2 - 0.25 g, from 3 to 7 years - 0.25 - 0.3 g, from 7 to 12 years - 0.3 - 0.5 g per day.
A solution of pasomycin can also be introduced into the fistulous passages and pleural cavity (0.25 - 0.5 g).
Pasomycin is dissolved in 2 - 3 ml of 0.25 - 0.5% solution of novocaine, isotonic sodium chloride solution or sterile water for injection. It is necessary to use a freshly prepared solution.
With prolonged use of the drug, disorders of the vestibular apparatus and a decrease in hearing acuity, skin itching, dermatitis, dizziness, and nausea are possible. Caution is required when prescribing pasomycin for acute and chronic nephritis (due to a possible delay in the release of the drug) and inflammation of the auditory nerve. Pasomycin should not be prescribed simultaneously with kanamycin, florimycin, monomycin and other antibiotics that have otoya nephrotoxicity.
Release form: in hermetically sealed vials of 0.5 and 1 g (500 000 and 1 000 000 units) per dihydrostreptomycin base (with the addition of a solvent - 0.5% solution of novocaine in ampoules).
Storage: List B. In a dry, dark place.