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Medication Description: Ethambutol (Ethambutolum)

ETAMBUTOL (Ethambutolum). (+) - N, N-Ethylene-bis- (2-aminobutan-1-ol), or (+) - N, N-bis [1- (hydroxymethyl) propyl] ethylene diimine dihydrochloride.

Synonyms: Diambutol, Miambutol, Afimocil, Ambutol, Anvital, Batacox , Cidanbutol, Clobutol, Dadibutol, Dexambutol, Diambutol, Ebutol, Etambin, Ethambutol, Farmabutol, Li-Butol, Miambutol, Myambutol, Mycobutol, Temibutol, Tibistal, Tubetol et al.

White crystalline powder. Easily soluble in water.

It has a pronounced tuberculostatic effect; it does not affect other pathogenic microorganisms. Suppresses reproduction of mycobacteria that are resistant to streptomycin, isoniazid, PAS, ethionamide, kanamycin. Well absorbed from the gastrointestinal tract; mainly excreted in urine.

Applied with the treatment of various forms of tuberculosis in combination with other anti-TB drugs. There is evidence of high efficacy of ethambutol in combination with rifampicin in patients with chronic destructive pulmonary tuberculosis (ethambutol 25 mg / kg per day; rifampicin 0.45 - 0.6 g once a day).

Ethambutol is taken orally once after breakfast. The optimal daily dose for adults is 25 mg / kg in 1 dose. This dose should be taken without reducing throughout the entire course of therapy (in recent years, ethambutol is prescribed in higher doses - 30-40 mg / kg by the intermittent method - every other day or 2 times a week). Children are prescribed at the rate of 20-25 mg / kg per day, but not more than 1 g.

The drug can be taken 2-3 times a week at a dose of 50 mg / kg (for adults).

When taking ethambutol, cough may increase, sputum may increase, dyspeptic symptoms, paresthesia, dizziness, depression, skin rash may appear, visual acuity deteriorates (reduction of the central or peripheral visual field, cattle formation). These phenomena usually disappear after drug withdrawal (after 2–8 weeks).

In the process of treatment, systematic monitoring of visual acuity, refraction, color perception and other indicators of the condition of the eye is necessary.

Contraindications: inflammation of the optic nerve, cataracts, inflammatory diseases of the eye, diabetic retinopathy, pregnancy.

Method of production: tablets of 0.1; 0.2 and 0.4 g per pack of 100 pieces.

Storage: List B.

Combunex (Combunex) *. Combined drug. Tablets containing 800 mg (0.8 g) of ethambutol and 300mg (0.3 g) of isoniazid.

Available in India.