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Description of the medicine: Thioacetasone (Thioacetazonum)

THIOACETASONE (Thioacetazonum).

Thiosemicarbazone para-acetaminobenzaldehyde:

Synonyms: Tibon, Ambathizonum, Amithiozon, Benzothiozone, Conteben, Diazan, Myvizon, Parazone, Tebethion, Thiomicid, Tibion, Tibisan, Tizone, Tubercazon, Tubigal, Vitazone, etc.

Light yellow fine crystalline powder, bitter in taste.

Almost insoluble in water, hardly soluble in alcohol.

Thioacetazone has bacteriostatic activity against Mycobacterium tuberculosis and the causative agent of leprosy. However, due to its relatively high toxicity, it is used to a limited extent: it is usually prescribed in combination with isoniazid, phthivazide, PASK, streptomycin and other anti-tuberculosis drugs to increase the therapeutic effect and reduce the possibility of resistant forms of mycobacterium tuberculosis. Combination with ethionamide is not recommended due to the cross-resistance of mycobacteria.

They are mainly used for tuberculosis of the mucous membranes and serous membranes, lymphadenitis, scrofuloderma, and specific fistulas.

With tuberculous meningitis is not prescribed.

In some cases, thioacetasone has a therapeutic effect in leprosy, most effective in the early stages of the disease.

The drug is taken orally after a meal; washed down with a glass of tea, water, milk.

The daily dose for adults is 0.1 - 0.15 g (0.05 g 2 - 3 times a day), for patients older than 60 years and body weight less than 50 kg - 0.1 g per day.

Children are prescribed 0.0005-0.001 g (0.5-1.0 mg) per 1 kg of body weight per day (not more than 0.05 g per day).

In the treatment of tuberculous empyema, sometimes 1% sterile suspension of thioacetazone (in oil, glycerin, isotonic sodium chloride solution) is used.

In the treatment with thioacetasone, headache, nausea, dermatitis, and a loss of appetite are possible. In rare cases, at high doses, albuminuria, hepatitis, sometimes leukopenia, thrombocytopenia, agranulocytosis, anemia develop. Albuminuria, cylindruria, and liver damage may appear.

Thioacetazone treatment should be carried out under close medical supervision with systematic monitoring of the functions of the kidneys, liver, and the state of the hematopoietic system. With the appearance of protein in the urine, severe allergic reactions, increasing anemia, jaundice, with the onset of agranulocytosis and other pronounced side effects, the drug is canceled.

Contraindications: impaired liver and kidney function, diseases of the hematopoietic system.

In the treatment of leprosy, thioacetazone should not be combined with diaphenyl sulfone (see).

Release form: tablets (light yellow color) at 0,025 and 0,05 g in a package of 100 pieces.

Storage: List B. In a dry, dark place.