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Description medications: Thioacetazone (Thioacetazonum)

Thioacetazone (Thioacetazonum).

Tiosemikarbazonami para-atsetaminobenzaldegida:

Synonyms: Tibon, Ambathizonum, Amithiozon, Benzothiozone, Conteben , Diazan, Myvizon, Parazone, Tebethion, Thiomicid, Tibion, Tibisan, Tizone, Tubercazon, Tubigal, Vitazone and others.

Light yellow crystalline powder with a bitter taste.

Almost insoluble in water, it is soluble in alcohol.

Thioacetazone has bacteriostatic activity against Mycobacterium tuberculosis and leprosy pathogen. However, due to the relatively high toxicity, its use is limited: usually prescribed in combination with isoniazid, ftivazid, PAS, streptomycin and other anti-TB drugs to improve the therapeutic effect and reduce the possibility of the emergence of resistant forms of Mycobacterium tuberculosis. Combine with ethionamide is not recommended due to the cross-resistance of mycobacteria.

Applied mainly in tuberculosis of the mucous and serous membranes, lymphadenitis, skrofuloderme specific fistulas.

If tuberculous meningitis is not appointed.

In some cases, thioacetazone has a therapeutic effect in leprosy, the most effective in the early stages of the disease.

The drug is taken orally after a meal; washed down with a glass of tea, water, milk.

The daily dose for adults of 0.1 - 0.15 g (0.05 g of 2 - 3 times per day) for patients older than 60 years of age and weighing less than 50 kg - 0.1 g per day.

Children appoint 0.0005 - 0.001 g (0.5 - 1, 0 mg) per 1 kg of body weight per day (up to 0.05 g per day).

In the treatment of tuberculous empyema, sometimes using 1% sterile slurry thioacetazone (in oil, glycerol, isotonic sodium chloride solution).

When treating thioacetazone possible headache, nausea, dermatitis, worsening of appetite. In rare cases, when large doses are developing albuminuria, hepatitis, sometimes leukopenia, thrombocytopenia, agranulocytosis, anemia. May appear albuminuria, cylindruria, liver damage.

thioacetazone Treatment should be under close medical supervision with regular monitoring of renal function, liver, state of the hematopoietic system. With the appearance of protein in the urine, expressed allergic reactions, increasing anemia, jaundice, with starting agranulocytosis and other drug expressed adverse events canceled.

Contraindications: violation of liver and kidney failure, diseases of the hematopoietic system.

In the treatment of leprosy should not be combined with tioatsetazon diafenilsulfonom (cm.).

Product: pills (light yellow) to 0,025 and 0.05 grams in a package of 100 pieces.

Storage: List B. In dry, dark place.