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Description medications: IFN (Reaferonum)

IFN (Reaferonum).

Recombinant interferon a 2 produced by bacterial strain of Pseudomonas, in the genetic apparatus which is built and a gene of human leukocyte interferon 2-. Identical to Human Leukocyte a 2 - interferon.

IFN - porous powder or porous mass of white. Soluble in water. Hygroscopic.

It possesses antiviral, immunomodulatory and antitumor activity.

Apply IFN in viral and neoplastic diseases.

The drug is effective in viral hepatitis. Assign an adult in the treatment of acute viral hepatitis B. The drug is most effective at the beginning of jaundice period until the 5th day of illness. When developed hepatic coma and cholestatic hepatitis during the drug is not very effective.

Reaferon used in viral conjunctivitis, keratoconjunctivitis, keratitis, uveitis, as well as hairy-cell leukemia, chronic myeloid leukemia, renal cancer. There is also evidence reaferona use in the treatment of multiple sclerosis.

Assign IFN intramuscularly subkonyunktivalno and locally.

For intramuscular administration the contents of 1 vial was dissolved immediately before use in 1 ml of isotonic sodium chloride solution.

In acute hepatitis B, is administered at 1,000,000 IU reaferona 2 times a day for 5 - 6 days, and then for 5 days at 1 million IU 1 time per day. If necessary, continue to impose on 1000000 IU 2 times a week for 2 weeks. The total dose per treatment reaferona 15 000 000 to 20 000 000 IU.

When hairy-cell leukemia is administered daily 3 000 000 6 000 000 IU for 2 months. Supportive therapy - 3 000 000 IU, 2 times a week. In the course of treatment 420 000 000 - 600 000 0000 IU.

In cancer, kidney (IV stage) reaferon administered at 3 million IU daily for 10 days. Courses (3 - 9 or more) is repeated every 3 weeks. The total amount of the preparation is up to 90 million IU 270 000 000 or more.

In multiple sclerosis, introduced by 1 million IU 3 times a day with pyramidal syndrome and 1 - 2 times a day - with cerebellar. Enter within 10 days, then reduce the number of administrations: the same dose 1 time per week for 5 - 6 months.

In ophthalmological practice reaferon used as subconjunctival injections and topically, as eye drops. For subconjunctival injection and instillation, the contents of 1 vial was dissolved in 5 ml of isotonic sodium chloride solution.

Subconjunctivally administered stromal keratitis at keratoiridotsiklite 60 and 000 IU in 0.3 mL daily or every other day depending on the severity of the process. The course of treatment 15 - 25 injections are performed under local anesthetic tetracaine 0.5% solution. Conjunctivitis and keratitis surface instilled into the conjunctival sac of the affected eye drops of 2, starting from 6 - 8 times a day, then 3 - 4 times daily. The course of treatment - about 2 weeks.

When using reaferona may be chills, malaise, fever, allergic skin reactions (rash, pruritus), leuko- and thrombocytopenia.