Description of the medicine: Bigumalum (Bigumalum)
N'-para-Chlorophenyl-N 5 - isopropylbiguanine hydrochloride.
Synonyms: Balusil, Chlorguanid, Chloriguane, Diguanil, Guanatol, Paludrine, Palusil, Plasin Proguanide, Proguanil hydrochloride, Proguanilum, Tirian.
Flavourless white crystalline powder, bitter taste. It is slightly soluble in water (1: 100 at + 20 C), it is difficult in alcohol. Aqueous solutions are sterilized at +100 C for 30 minutes.
By the type of action on malarial plasmodium, bigumal is close to chloridine, the duration of action is shorter compared to chloridine. The effect is slower than with hingamine (chloroquine) and acrychin. Due to the relatively slow onset of the effect, the rapid release from the body and the rapid development of drug resistance to it of malarial plasmodia, bigumal is used to a limited extent. In the treatment of tropical malaria, it is prescribed only for moderate severity.
Take orally after a meal. Wash down with water (1/4 - 1/2 cup). On the course (4 - 5 days), adults are prescribed 1, 5 g according to the following scheme:
Day Daily Number of treatment doses, g per day
1st 0.6 2 doses with an interval of 6 hours 2 - 4th 0.3 1 dose
Note. On the 1st day, the daily dose may be 0.3 g; in this case, the course of treatment lasts 5 days.
In severe cases of the disease, treatment can last up to 7 days; the daily dose from the 2nd to the 7th day is 0.3 g (in 1 dose).
Higher doses of bigumal for adults inside: single 0.3 g daily 0.6 g.
For children, the dose is reduced in accordance with age.
Age Daily doa, g
Up to 1 year ......... 0,025 1 - 2 >> ........ 0,05 3 - 4 >> ........ 0,075 5 - 6 years ... ...... 0.1 7 - 8 >> ........ 0.15 9 - 12 >> ........ 0.15 - 0.2 13 - 16 >> ........ 0.25
Older than 16 years old ... 0.3
The course of treatment is 5 days. The daily dose is prescribed in one step. Children over 16 years of age on the 1st day can be given 0.6 g; in this case, the treatment lasts 4 days.
With unconsciousness and vomiting, 1% solution of bigumal is injected into a vein. At the first injection, 10-15 ml is administered, if necessary, repeat the injection with an interval of 4-6 hours.
A single dose should not exceed 0.15 g (15 ml of a 1% solution), daily - 0.45 g.
For injection, a 1% solution of bigumal is prepared in a 0.5 - 0.6% isotonic sodium chloride solution. The solution is filtered and sterilized at + 100 ° C for 30-40 minutes.
Enter into a vein in a warmed form; crystals of bigumal may precipitate upon cooling.
After restoration of consciousness, Bigumal is prescribed orally in a daily dose of 0.3 g; the course of treatment for malaria coma is 7 days.
For malaria chemoprophylaxis, Bigumal is prescribed at 0.2 g (2 tablets) 2 times a week (for example, on the 1st and 4th days of the week).
Bigumal is usually well tolerated. Sometimes the number of leukocytes in the peripheral blood increases briefly and young forms of neutrophils appear, and red blood cells are found in the urine in a small amount.
Long-term use of bigumal can cause inhibition of gastric secretion and loss of appetite, which often occurs when taking the drug on an empty stomach.
The disadvantages of bigumal are slow action, rapid elimination from the body and the rapid development of malaria plasmodia resistance to it.
Method of release: tablets and dragees of 0.1 g for adults and 0.05 g for children; powder.
Storage: List B.