Description medications: Griseofulvin (Griseofulvinum)

Griseofulvin (Griseofulvinum).

An antibiotic produced by mold fungi Penicillium nigricans (griseofulvum). The chemical structure is hlor2 7 ', 4, 6-trimethoxy-6'-2'-metilgrizen-dione-3, 4'.

Synonyms: Gritsina, Biogrisin, Fulcin, Fulvicin, Fulvina , Fulvistatin, Fungivin, Greosin, Gricin, Grifulin, Grifulvin, Grisactin, Grisefuline, Grisovin, Lamoryl, Likuden, Neo-Fulcin, Sporostatin and others.

Griseofulvin is an antifungal agent having fungistatic effect on various types of dermatomitsetami (Trichophyton, mikrosporum, epidermofiton).

Ineffective for candidiasis. An important feature is its effectiveness griseofulvin ingestion.

griseofulvin activity to some extent depends on the fineness of its crystals and related surface area powder. The usual fine-grained form of the drug is about 2 times less active than specially made finely divided form, previously called griseofulvin forte.

Currently mainly used drug finely whose most particles size less than 4 microns.

The product is white or white with a yellowish tinge naimelchayshy crystalline powder with low specific (mushroom) odor. Practically insoluble in water, slightly soluble in alcohol.

Griseofulvin is one of the basic means of treatment of patients dermatomycoses. It is prescribed in the treatment of patients with crusted ringworm, and trichophytosis microsporia scalp and smooth skin, athlete's smooth skin, caused by trihofitonom and nail lesions (onychomycosis), caused by pathogenic fungi (Trichophyton, red epidermofiton).

Take griseofulvin interior and local.

For oral administration available in the form of tablets (0,125 g) and a suspension (1 ml containing 0.1 g of griseofulvin); for topical application - in the form of 2, 5% liniment.

The tablets are taken orally with meals (with 1 teaspoon of vegetable oil). The suspension is designed for children up to 3 years of age. Liniment used independently with limited skin lesions, and in combination with oral medication.

When microsporia designate an adult to 8 tablets per day, children - at the rate of 21 - 22 mg / kg per day. The drug is taken daily to assay the first negative mushrooms, then at the same dose for 2 weeks every second day and 2 weeks, 2 times a week.

When trihofitii (superficial and infiltrative-suppurative forms) and favus, adults prescribed the same dose, the children - 18 mg / kg (in the same way).

In the process of treatment in patients with fungal infections of the scalp must be weekly shave, wash with soap and water head 2 times a week. It is recommended to rub into the scalp antifungal ointments and lubricate the pockets of 2 - 3% alcoholic solution of iodine.

When onychomycosis, Trichophyton and crusted ringworm of the scalp daily dose of griseofulvin for adults weighing up to 50 kg of 5 tablets (625 mg), and higher body weight is added for every 10 kg: 1 tablet, but not more than 1 g (8 tablets) per day.