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Medication Description: Griseofulvin (Griseofulvinum)

GRIZEOFULVIN (Griseofulvinum).

Antibiotic produced by the fungus Penicillium nigricans (griseofulvum). According to the chemical structure, it is 7-chloro2 ', 4, 6-trimethoxy-6'-methylgrizen-2'-dione-3, 4'.

Synonyms: Gritsin, Biogrisin, Fulcin, Fulvicin, Fulvina, Fulvistatin, Fungivin, Greosin, Gricin, Grifulin, Grifulvin, Grisactin, Grisefuline, Grisovin, Lamoryl, Likuden, Neo-Fulcin, Sporostatin, etc.

Griseofulvin is antifungal agent that has a fungistatic effect on various types of dermatomycetes (trichophytons, microsporums, epidermofitony).

Ineffective with candidiasis. An important feature of griseofulvina is its effectiveness when taken orally.

The activity of griseofulvin to a certain extent depends on the dispersion of its crystals and the associated specific surface of the powder. The usual fine-crystalline form of the drug is about 2 times less active than the specially manufactured highly dispersed form, previously called griseofulvin forte.

Currently, a highly dispersed preparation is mainly used, in which the size of most particles is no more than 4 microns.

The drug is a white or white with a yellowish tinge the smallest crystalline powder with a weak specific (mushroom) odor. Practically insoluble in water, slightly soluble in alcohol.

Griseofulvin is one of the main means of treating patients with ringworm. It is prescribed for the treatment of patients suffering from favus, trichophytosis and microsporia of the scalp and smooth skin, smooth skin epidermophytosis caused by trichophyton, and nail lesions (onychomycosis) caused by pathogenic fungi (trihofiton, red epidermofiton).

Take griseofulvin inside and local.

For ingestion comes in the form of tablets (0.125 g each) and as a suspension (1 ml contains 0.1 g of griseofulvin); for local use - in the form of 2, 5% liniment.

Tablets are taken orally during meals (with 1 teaspoon of vegetable oil). Suspension is intended for children up to 3 years of age. Liniment is used alone with limited skin lesions and in combination with the drug intake.

For microsporia, adults are prescribed 8 tablets per day, for children - at the rate of 21-22 mg / kg per day. The drug is taken daily until the first negative test for mushrooms, then at the same dose for 2 weeks every other day and 2 weeks 2 times a week.

With trichophytosis (superficial and infiltrative-suppurative forms) and favus, adults are prescribed the same dose, children 18 mg / kg each (according to the same scheme).

In the process of treatment in patients with mycosis of the scalp, it is necessary to shave the hair weekly, wash your head with soap and water 2 times a week. It is recommended to rub antifungal ointments into the scalp and lubricate the lesions with 2 to 3% alcohol solution of iodine.

With onychomycosis, trichophytosis and a favus of the scalp, the daily dose of griseofulvin for adults weighing up to 50 kg is 5 tablets (625 mg), and for most body weight add 1 tablet but not more than 1 g (8 tablets) per day.