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Description of the medicine: Terbinafine (Terbinafine)

TERBINAFINE (Terbinafine). (E) -N- (6, 6-Dimethyl-2-hepten-4-ynyl) - N-methyl-1-naphthalenemethanamine.

Available in the form of hydrochloride.

Synonyms: Lamizil, Lamizyl (the name of the drug is "SANDOZ").

Antifungal drug for oral and external use. It has a wide range of antifungal activity. It has a fungicidal effect on dermatomycetes, mold fungi and some dimorphic fungi. The mechanism of action is associated with the suppression of the biosynthesis of sterols in the cell membrane of the fungus.

When applied topically (in the form of a cream), the drug is slightly absorbed and has a slight systemic effect. With oral administration (in the form of tablets), the maximum concentration in blood plasma is observed within 2 hours; the drug is firmly bound to plasma proteins.

The drug quickly diffuses through the skin and accumulates in the sebaceous glands. It is excreted with sebum, while relatively high concentrations are created in the hair follicles and hair. Within a few weeks after the start of use, it also penetrates the nail plates.

Inside, terbinafine (in the form of tablets) is used for fungal skin lesions caused by dermatomycetes (trichophytosis, microsporia), for yeast infections of the skin, fungal infections of the nails (onychomycosis). Terbinafine is also used to treat pityriasis (multicolored) lichen.

Assign to adults inside at a dose of 0.125 g (125 mg) 2 times a day or 0.25 g 1 time per day (regardless of the meal time). The duration of treatment depends on the evidence and severity of the infection. Typically, the duration of treatment of skin lesions is 2 to 4 weeks, nail lesions - from 6 weeks to 4 months (sometimes longer).

The drug is generally well tolerated. In some cases, dyspeptic symptoms, skin allergic reactions are possible.

Terbinafine should not be prescribed during pregnancy and lactation, as well as children (due to lack of sufficient data). In elderly patients, there may be impaired liver and kidney function.

Terbinafine cream (lamisil) is used externally for fungal skin lesions caused by dermatomycetes, for yeast infections of the skin (candidiasis), lichen (pityriasis or multicolored). The cream is applied in a thin layer on the affected surfaces and adjacent areas 1-2 times a day, gently rubbed.

Apply depending on the severity of the lesion and effectiveness for 1 - 2 - 4 honey. Usually the therapeutic effect is observed in the first few days.

The cream is well tolerated. In some cases, there is hyperemia, itching, a burning sensation, usually not requiring discontinuation of treatment.

Method of release: tablets containing 0.125 or 0.25 g of terbinafine (hydrochloride); 1% ointment in tubes.

Storage: tablets are stored in a dark place.