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Medication Description: Angiazol

Corazolum (Corazolum) 1, 5- Pentamethylenetetrazole.

Synonyms: Angiazol, Cardiazol, Centrazol, Deumacar, Diovascol, Leptazol, Metrazol, Pentamethazolum, Pentazol, Pentetrazolum, Pentrazol, Pentylentetrazol, Phrenazole, Tetracor and others.

White crystalline powder. Very easily soluble in water and alcohol. Aqueous solutions (pH 6, 0 - 8, 0) are sterilized at + 100 C for 30 minutes.

It has an exciting effect on the respiratory and vasomotor centers. Excitation of respiration, increased blood pressure, and improved blood circulation are particularly pronounced if these centers of the medulla oblongata are in a depressed state. The drug has no direct effect on the heart and blood vessels.

In large doses causes the excitation of the brain and spinal cord and can have an "awakening" effect in acute poisoning with sleeping pills and drugs. In high doses, the corazole also has a convulsive effect, associated mainly with the effect on the motor zones of the brain and only partially with the effect on the spinal cord.

In the past, corazole was widely used for shock, asphyxia, weakened cardiac activity, during surgical interventions, as well as poisoning with narcotic drugs, sleeping pills, analgesics.

In psychiatric practice, they used corazole for convulsive therapy of schizophrenia.

Recently, the use of corazole (and other analeptics) for poisoning with hypnotics has been considered inappropriate, since the need for a brain in oxygen increases. In addition, a more specific means for poisoning with barbiturates and other means for anesthesia is bemegrid (see). When poisoning with narcotic analgesics began to use a specific antagonist - naloxone (see).

In psychiatric practice, corazol is also not currently used.

In this regard, korazol is excluded from the nomenclature of medicines.

At the same time, corazol remains a very valuable tool for experimental pharmacological studies. They are widely used in the search and study of anticonvulsants and other neuro (psycho) tropic drugs.