Description of the medicine: Piperazine (Piperazinum)

Piperazinum.

Diethylenediamine.

Piperazine and its salts have an antihelminthic effect on various species of nematodes, especially those that cause ascariasis and enterobiosis (pinworm infestations). They act on both sexually mature and immature individuals of both sexes.

Piperazine causes paralysis of the musculature of helminths; In the future they are excreted by peristaltic movements of the intestine. In 90 - 95% of cases, piperazine releases the body from parasites, with repeated application it is possible to achieve almost 100% de-worming.

Piperazine drugs are rapidly absorbed when taken orally. Excreted mainly by the kidneys. Their use does not require preliminary preparation of patients or maintenance on a special diet. Laxatives are prescribed only if prone to constipation; Give them on the days of piperazine in the evening.

Piperazine preparations are low in toxicity and do not usually cause side effects in therapeutic doses; Can be used in outpatient settings. Sometimes there is mild nausea, abdominal pain, transient headache. When an overdose is possible, muscle weakness, tremor. In patients with impaired renal excretory function, neurotoxic events may occur.

Contraindications: organic diseases of the central nervous system.

The main product of piperazine, used as an antihelminthic agent, is piperazine adipate.

Piperazine adipate (Piperazini adipinas).

Synonyms: Adipalit, Adiprazina, Entacyl, Entazin, Helmirazin, Heltolan, Nematocton, Nometan, Oxurasin, Piperascat, Piperazine adipate, Piperazinum adipinicum, Vermicompren, Vermitox and others.

White crystalline powder odorless. Soluble in water, easily - in hot, almost insoluble in alcohol and ether.

When treating ascaridosis, the drug is prescribed for 2 consecutive days 2 times a day for 1 hour or 1/2 to 1 hour after a meal. They are given orally in the form of tablets in the following doses for a single dose: adults - 1, 5 - 2, 0 g (3 - 4 g per day); Children under 1 year - 0.2 g (0.4 grams per day), from 2 to 3 years - 0.3 g (0.6 grams per day), from 4 to 5 years - 0.5 grams (1 g per day); From 6 to 8 years - 0.75 g (1, 5 g per day), from 9 to 12 years - 1 g (2 grams per day), from 13 to 15 years - 1, 5 grams (3 grams per day). Children can be prescribed as a 5% solution.

You can also take the drug for one day: once from 0.4 to 4 g (depending on age) or 2 times from 0.2 to 2 g.

A solution of piperazine adipinate 5% for children (Solutio Piperazini adipinatis 5% pro infantibus). Contains in 100 ml of piperazine adipate 5 g, acid citric 2 g, sugar syrup 72, 9 g, sodium benzoate 0.1 g, water 20 ml. Transparent liquid of slightly yellow color, odorless, sweet and sour to taste. One teaspoon of the solution contains 0.25 g of piperazine adipate, a dessert spoon - 0.5 g, a tablespoon - 0.75 g.

When enterobiosis is taken in the same doses for 5 consecutive days with a 7-day break; Spend 1 - 3 cycles of treatment. In between cycles, it is recommended to put an enema for the night (to remove pinworm from the rectum); Adults from 4 to 5 glasses of water, children - from 1 to 3 glasses with the addition of sodium bicarbonate, 1/2 teaspoon per glass of water.

Children can be assigned a ready 5% solution.

In the treatment of enterobiosis, strict adherence to the hygiene regime is necessary.