Description of the drug: Ditrazina citrate (Ditrazini citras)
DITRAZINA CITRATE (Ditrazini citras). 1-Methyl-4-diethylcarbamoyl piperazine citrate.
Synonyms: Loxuran, Banocide, Carbamazine, Carbilazine, Caricid, Citrazan, Decazine, Diaethylcarbamazini citras, Ditrazinum citricum, Filabran, Hetrazan, Notezine, Supatonin, Unicarbazan, etc.
White crystalline powder. Very easily soluble in water, it is difficult to alcohol.
Ditrazin has the main use in the treatment of filariasis (wuchereriasis, Brugioz, onchocerciasis, acanthohelenyenosis). It also acts on ascariasis, but is less effective than piperazine and its salts, and more toxic.
Assign with oral filariasis, at the rate of 2 mg / kg 3 times a day for 10 days. The daily dose should not exceed 0.4 g. Depending on tolerability and effectiveness, they spend from 3 to 5 courses (with an interval of 10 - 12 days). Efficacy is determined by the disappearance of microfilariae in the blood and clinical manifestations of the disease (skin rash, hypereosinophilia, etc.).
When using the drug, side effects are relatively common: pruritus, the appearance or enhancement of skin rashes, less often cough, eosinophilic infiltrates, lymphadenopathy, sometimes an increase in the size of the liver and spleen, etc. or loss of vision). Therefore, the drug in onchocerciasis, accompanied by damage to the eye media, is contraindicated.
With pronounced side effects, the drug is temporarily canceled, and desensitization therapy is carried out.
It is not necessary to prescribe steroid drugs at the same time as ditrazine, since the suppression of the lymphoid tissue may increase the activity of the parasites.
Method of production: powder, tablets of 0.05 and 0.1 g in a package of 30 and 50 pieces.
Storage: List B. In a well-closed container.