Description of the medicine: Ditrazin citrate (Ditrazini citras)
DITRAZINE CITRATE (Ditrazini citras). 1-Methyl-4-diethylcarbamoylpiperazine citrate.
Synonyms: Loxuran, Banocide, Carbamazine, Carbilazine, Caricid, Citrazan, Decazine, Diaethylcarbamazini citras, Ditrazinum citricum, Filabran, Hetrazan, Notezine, Supatonin, Unicarbazan and others.
White crystalline powder. Very easily soluble in water, it is difficult in alcohol.
Ditrazine has the main application in the treatment of filariasis (vukhereriosis, brugia, onchocerciasis, acanthoheylenematosis). It also works with ascariasis, but is less effective than piperazine and its salts, and is more toxic.
Assign for filariasis inside, at a rate of 2 mg / kg 3 times a day for 10 days. The daily dose should not exceed 0.4 g. Depending on the tolerability and effectiveness, 3 to 5 courses are conducted (with an interval of 10 to 12 days). Efficacy is determined by the disappearance of microfilariae and clinical manifestations of the disease in the blood (skin rash, hypereosinophilia, etc.).
When applying the drug relatively often there are side effects: skin itching, the appearance or enhancement of skin rashes, less often - cough, eosinophilic infiltrates, lymphadenopathy, sometimes an increase in the size of the liver and spleen, etc. In onchocerciasis, inflammation in the eyes may worsen (vitreous turbidity, weakening Or loss of vision). Therefore, the drug with onchocerciasis, accompanied by damage to the eyes, is contraindicated.
At sharply expressed by-effects the drug is temporarily canceled, desensitizing therapy is carried out.
Do not use steroid preparations at the same time as ditrazine, since the suppression of lymphoid tissue can increase the activity of parasites.
Form release: powder, tablets of 0.05 and 0.1 g in a package of 30 and 50 pieces.
Storage: List B. In a well ukuporennoy container.