Medication Description: Chlorhexidine (Chlorhexidinum)
Chlorhexidine (Chlorhexidinum). 1, 6-Di- (para-chlorophenyl-guanido) -hexane.
Synonyms: Gibitan, Sebidin, Hibitan, Abacil, Biotensid, Chlorohex, Corsodyl, Fimeil, Hexadol, Hexol, Hibitane, Nolvasan, Plivasept, Rotersept, Sebidin, Septalone, Soretol, Sterilone, etc.
Available in the form of digluconate (Chlorhexidini bigluconas).
Chlorhexidine is one of the most active local antiseptics.
Chemically, it is a dichloro-containing biguanide derivative. The structure is very close to biguma (see).
Chlorhexidine has a fast and strong bactericidal effect on gram-positive and gram-negative bacteria. No effect on viruses and spores.
The drug is stable and after treating it with skin (hands, surgical field, etc.) it is stored on it in some quantity, which continues to give a bactericidal effect. The drug retains activity in the presence of blood, pus, although somewhat reduced.
Chlorhexidine is also effective against pathogens of sexually transmitted diseases: treponema, gonokokkov, Trichomonas.
Used for the treatment of the surgical field and the hands of the surgeon, sterilization of surgical instruments, as well as for purulent-septic processes (washing the operating wounds, bladder, etc.) and for the prevention of sexually transmitted diseases (syphilis, gonorrhea, trichomoniasis).
The drug is available in the form of a 20% aqueous solution. For the treatment of the operative field, dilute the 20% solution with 70% ethanol in the ratio of 1:40. The resulting 0.5% aqueous alcoholic solution of chlorhexidine digluconate is treated with a surgical field 2 times with an interval of 2 minutes. For rapid sterilization of instruments, use the same solution for 5 minutes.
For disinfection of wounds, burns, use 0.5% aqueous solution; for hand disinfection - 0.5% alcohol solution or 1% aqueous solution.
When using the drug to treat the surgeon's hands, transient dryness and itching of the skin, dermatitis are possible; stickiness of the skin of the hands for 3 - 5 minutes is also possible.
The drug is contraindicated in the propensity to allergic reactions and with dermatitis. It is undesirable to use iodine at the same time to avoid the development of dermatitis. Do not use chlorhexidine solutions to treat the conjunctiva and to rinse cavities.
A 0.1% aqueous solution of chlorhexidine digluconate can also be used for general disinfection of premises, sanitary equipment, etc.
Product form: 20% aqueous solution in bottles of 0.5; 3 and 5 l.
Storage: protected from light at room temperature.
For individual prevention of sexually transmitted diseases, it is produced in the form of a 0.05% solution in a special plastic package of 100 ml each.
Disteril (Disteril), produced abroad, contains 1.5% chlorhexidine digluconate and 15% benzalkonium (surface-active antiseptic), as well as a dye. Adding benzalkoniya enhances the disinfecting effect, and the dye allows you to accurately determine the area of the treated skin. It is used for the treatment of the surgical field, disinfection of medical equipment.