Description of the medicine: Hexamethylenetetramine (Hexamethylentetraminum)
Synonyms: Urotropin, Aminoform, Cystamine, Cystogen, Formamin, Hexamethylentetramin, Hexamina, Methenamine, Metramine, Urisol, Urotropinum, etc.
Colorless crystals or a white crystalline powder of a burning and sweet and then bitter taste, odorless. Easily soluble in water (1: 1, 5) and alcohol (1:10). When heated, it evaporates without melting. Burns with a pale flame.
Aqueous solutions have an alkaline reaction (pH of a 40% solution of 7, 8 - 8, 2). For intravenous administration, the solution is prepared aseptically.
Obtaining hexamethylenetetramine was the first experiment (1899) to create a medicinal substance, which is now called a prodrug (see Phenyl salicylate). With the breakdown of hexamethylenetetramine in the body (in an acidic environment), formaldehyde is released, which, when excreted in the urine, has an antiseptic property.
Hexamethylenetetramine is used as an antiseptic in infectious processes in the urinary tract (cystitis, pyelitis).
With an alkaline urine reaction, formaldehyde does not cleave and there is no curative effect. In these cases, substances are prescribed that shift the reaction of urine to the acid side (see Ammonium chloride).
To prevent the breakdown of hexamethylenetetramine in the stomach, it is prescribed on an empty stomach. If necessary, a solution of hexamethylenetetramine is administered intravenously.
Indications for the use of hexamethylenetetramine are also cholecystitis and cholangitis, allergic skin diseases (urticaria, polymorphic erythema, etc.), eye diseases (iridocyclitis, keratitis, etc.). The drug is also used for meningitis, encephalitis, arachnoiditis.
Currently, due to the presence of more effective agents, hexamethylenetetramine is not widely used.
Assign inside in tablets and solutions to adults at 0.5 - 1, 0 g per reception, for children - 0.1 - 0.5 g; take several times a day. 5 to 10 ml of a 40% solution is injected into a vein.
Hexamethylenetetramine can cause irritation of the renal parenchyma and, in some cases, contribute to the spread of the disease process in pyelitis. If signs of kidney irritation are detected, the drug is stopped.
Method of release: powder; tablets of 0.25 and 0.5 g; 40% solution in ampoules of 5 and 10 ml.
Storage: in well-closed containers; solutions - at a temperature not exceeding + 20 C.
Hexamethylenetetramine is an integral part of the combined tablets <Calcex> and <Urobesal> (see Phenyl salicylate). Previously produced Urosal tablets, each containing 0.3 g of hexamethylenetetramine and phenyl salicylate, are excluded from the list of medicines.
Tablets <Calcex> (Tabulettae <Calcex>). Pills of white color, bitter taste. Easily soluble in water. Contain 0.5 g of a complex salt of hexamethylenetetramine and calcium chloride. Apply 1-2 tablets 3-4 times a day for colds. Previously, the drug was relatively widely used.