Medication Description: Hexamethylenetetramine (Hexamethylentetraminum)
Synonyms: Urotropin, Aminoform, Cystamine, Cystogen, Formamin, Hexamethylentetramin, Hexamina, Methenamine, Metramine, Urisol, Urotropinum, etc.
Colorless crystals or white crystalline powder burning and sweet, and then a bitter taste, odorless. Easily soluble in water (1: 1, 5) and alcohol (1:10). When heated evaporates without melting. Burns with a pale flame.
Aqueous solutions are alkaline (pH 40% solution 7, 8 - 8, 2). For intravenous administration, the solution is prepared aseptically.
The preparation of hexamethylenetetramine was the first experiment (1899) to create a drug substance, which is currently called a prodrug (see Phenyl salicylate). With the breakdown of hexamethylenetetramine in the body (in an acidic environment), formaldehyde is released, which has antiseptic properties when excreted in the urine.
Hexamethylenetetramine is used as an antiseptic for infectious processes in the urinary tract (cystitis, pyelitis).
When alkaline urine removal of formaldehyde does not occur and the therapeutic effect is not observed. In these cases, prescribe substances that shift the reaction of the urine in the acidic side (see Ammonium chloride).
To prevent the breakdown of hexamethylene tetramine in the stomach, it is prescribed on an empty stomach. If necessary, enter a solution of hexamethylenetetramine intravenously.
Indications for the use of hexamethylenetetramine are also cholecystitis and cholangitis, allergic skin diseases (urticaria, polymorphic erythema, etc.), eye diseases (iridocyclitis, keratitis, etc.). The drug is also used in meningitis, encephalitis, arachnoiditis.
At present, due to the availability of more effective agents, hexamethylenetetramine has not been widely used.
Assign inside tablets and solutions for adults at 0.5 - 1, 0 g per reception, for children - at 0.1 - 0.5 g; take several times a day. In the vein injected with 5 - 10 ml of 40% solution.
Hexamethylenetetramine may cause irritation of the renal parenchyma and in some cases contribute to the spread of the disease process during pyelitis. If there is evidence of irritation of the kidneys, the drug is stopped.
Method of issuance: powder; tablets of 0.25 and 0.5 g; 40% solution in ampoules of 5 and 10 ml.
Storage: in a well-closed container; solutions - at a temperature not higher than + 20 C.
Hexamethylenetetramine is an integral part of the Calcex and Urobesal combined tablets (see Phenyl Salicylate). Previously released tablets <Urosal>, containing 0.3 g of hexamethylenetetramine and phenylsalicylate, are excluded from the range of medicines.
Tablets <Calcex> (Tabulettae <Calcex>). Tablets of white color, salt taste. Easily soluble in water. Contain 0.5 g of the complex salt of hexamethylenetetramine and calcium chloride. Apply 1 to 2 tablets 3 to 4 times a day for colds. Previously, the drug was relatively widely used.