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Description medications: hexamethylenetetramine (Hexamethylentetraminum)

Hexamethylenetetramine (Hexamethylentetraminum).

Synonyms: Urotropin, Aminoform, Cystamine, Cystogen, Formamin , Hexamethylentetramin, Hexamina, Methenamine, Metramine, Urisol, Urotropinum and others.

Colourless crystals or white crystalline powder burning and sweet, then bitter taste, and odorless. Easily soluble in water (1: 1, 5) and ethanol (1:10). When heated, it evaporates without melting. Lit pale flame.

Aqueous solutions are alkaline (pH of 40% solution 7 8 - 8: 2). For intravenous solution is prepared aseptically.

Getting hexamethylenetetramine was the first experience (1899) the creation of the drug, which is now called a prodrug (see. Fenilsalitsilat). If the hexamethylenetetramine decomposition in an organism (in acidic media) is released formaldehyde during injection having antiseptic properties with urine.

Apply hexamethylenetetramine as an antiseptic in infectious processes in the urinary tract (cystitis, pielity).

In alkaline urine formaldehyde cleavage does not occur and the therapeutic effect is not observed. In these cases, the substance administered shifting reaction in urine acidic side (see. Ammonium chloride).

To prevent cleavage of hexamethylenetetramine in the stomach it is administered on an empty stomach. If necessary, enter hexamethylenetetramine solution intravenously.

Indications for the use of hexamethylenetetramine are used as cholecystitis and cholangitis, allergic skin diseases (urticaria, erythema multiforme, and others.), Diseases of the eye (iridocyclitis, keratitis, etc.). The drug is also applicable with meningitis, encephalitis, arachnoiditis.

Currently, due to the presence of more effective means, hexamethylenetetramine has wide application.

Assign inside tablets and solutions for adults 0,5 - 1, 0 g per reception, the children - 0.1 - 0.5 g; It takes several times a day. Injected into a vein at 5 - 10 ml of a 40% solution.

Hexamethylenetetramine can cause irritation kidney parenchyma and in some cases, contribute to the spread of the disease process when pyelitis. If you notice signs of renal irritation stop taking the drug.

Method of issuance: powder; tablets of 0.5 g and 0.25; 40% solution in ampoules 5 and 10 ml.

Storage: Keep in a well closed container; solutions - at a temperature no higher than + 20 ° C

Hexamethylenetetramine is part of the combined pill <calcex> and <Urobesal> (see. Fenilsalitsilat). Previously issued pill <Urosal> that contained 0.3 g of phenyl salicylate and hexamethylenetetramine, are excluded from the range of medicines.

Tablets <calcex> (Tabulettae <Calcex>). Tablets of white color, solenogorkie taste. Easily soluble in water. Contained 0.5 g of hexamethylenetetramine complex salt and calcium chloride. Apply 1 - 2 tablets 3 - 4 times a day for colds. Earlier drug has a relatively wide application.