Description of the medicine: Phenyl salicylate (Phenylii salicylas)

Phenyllsalicylate (Phenylii salicylas).

Phenyl ester of salicylic acid.

Synonyms: Salol, Phenylium salicylicum, Salolum.

White crystalline powder or small colorless crystals with a weak odor. Virtually nerastvorim in water, soluble (1:10) in alcohol, solutions of caustic alkalis.

Phenylsalicylate (salol) was synthesized long ago (in 1886, L. Nencki) in order to create a drug that would not disintegrate in the acidic contents of the stomach and did not act irritatingly on the gastric mucosa, and splitting in the alkaline contents of the intestine would release the acid salicylic and phenol. Phenol would act depressingly on the pathogenic microflora of the intestine, salicylic acid would have some antipyretic and anti-inflammatory effect, and both compounds, partially excreted from the kidneys, would disinfect the urinary tract.

This principle ("salol" principle - the principle of Nenets) was essentially one of the first experiments of creating prodrugs (see also Hexamethylenetetramine).

For a long time, phenylsalicylate has been widely used in diseases of the intestine (colitis, enterocolitis), with cystitis, pyelitis, pyelonephritis.

Compared with modern antibacterial drugs: antibiotics, sulfonamides, fluoroquinolones, etc. - phenyl salicylate is much less active. At the same time, it is low-toxic, does not cause dysbiosis and other complications and continues to be sometimes used in outpatient practice (often in combination with other drugs) for mild forms of these diseases. In more severe forms of disease, it is necessary to use more active drugs.

Assign phenylsalicylate orally to 0.25-0.5 g for reception 3 to 4 times a day, often in combination with antispasmodic astringents and other means.

Form release: powder, tablets of 0.25 and 0.5 g and various combination tablets: a) tablets <Besalol> (Tabulettae <Besalolum>); Composition: phenyl salicylate 0.3 g, belladonna extract 0.01 g; B) tablets <Urobesal> (Tabulettae << Urobesalum >>); Composition: phenyl salicylate and heximethylenetetramine 0.25 g, bellows extract 0.015 g; C) tablets << Tansal >> (Tabulettae <Tansalum>); Composition: phenyl salicylate and tanalbine, 0.3 g; D) phenyl salicylate and bismuth nitrate, basic 0.25 g, belladonna extract 0.015 g.

Fenkortozol (Phencortosolum). Contains phenylsalicylate and hydrocortisone acetate. It is used as a photoprotective and anti-inflammatory agent in photodermatoses, discoid lupus erythematosus. The course of treatment is 7-10 days. If necessary, repeat the course of treatment after 5 to 7 days.

Form release: emulsion in aerosol cans with a capacity of 55 g.

When the cylinder valve is pressed for 1 to 2 seconds, 7 to 14 cm of foam (0.7 to 1.4 grams of foam) is sufficient to cover 500 from the skin surface. At a time, it is possible to apply up to 30 cm of foam to the skin. The foam is evenly rubbed into the skin by massaging movements.

Do not use the drug on sunny days of cold seasons.

Storage: at a temperature not exceeding 40 ° C.