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Description medications: Sanguirythrine (Sanguiritrinum)

Sanguirythrine (Sanguiritrinum).

The amount of bisulphate alkaloids sanguinarine and heletrina contained in the plant heart-Maclay (Macleaya cordata Will.) And Muckle small-fruited (Masleaua microcarpas), Sem. poppy (Raraveraseae). Both alkaloid are sulfometilatami and contain quaternary nitrogen atoms.

Crystalline powder from light orange to dark orange. It is soluble in water, practically insoluble in alcohol.

It has antimicrobial activity against gram-positive and gram-negative bacteria. It acts on the yeast and filamentous fungi.

Sangviritrin Apply topically for the treatment of infected wounds, pyoderma, eczema, ringworm, periodontal disease, canker sores and other lesions of the oral mucosa.

When pyoderma and other skin diseases is used as a 1% or 0.2% liniment alcoholic solution.

Burns also appoint Liniment 1% or 0.1% aqueous solution.

The solutions were applied 1 - 2 times a day, liniment - 1 times a day every day or every 1 - 2 days (dressings).

For the treatment of periodontal disease are turundas wetted hydroalcoholic 0.2 or 0.01% - 0.1% aq. When stomatitis sangviritrin used in the form of applications or liniment 1% aqueous solution 2 - 3 times a day for 2 - 5 days.

The drug is generally well tolerated. In some cases, it may be a burning sensation or pain that can be avoided by adding a 0.5% solution of novocaine.

Sanguirythrine also has anticholinesterase activity. Sometimes he was appointed interior for the same indications, which use other anticholinesterase agents (see cholinesterase inhibitors.): With myopathy, the effects of polio, and others.

Assign these cases inside a pill (after eating) adults: 1 - 2 tablets (0.005 - 0.01 g), 2 times per day (up to 3 tablets per day), the children - at lower doses, depending on the age (not 0.001 g of a 1-year life of a day in 2 divided doses).

Oral administration is contraindicated in epilepsy, hyperkinesis, asthma, angina, liver and kidneys.

Using the drug into possible nausea, vomiting, abdominal pain.

Method of issuance: 1% liniment in orange glass jars, 20 g; 0.2% solution in bottles of 10 ml; 0,005 g of tablets (5 mg). Aqueous solutions Sanguirythrine prepared ex tempore of tablets, dissolving them in hot water.

Storage: List B. In the dark spot.