Description of the medicine: Chlorbutin (Chlorbutinum)

Chlorbutinum. 3- [para-bis-b-Chloroethyl) -aminophenyl] butyric acid.

Synonyms: Leukeran, Chlorambucil, Amboclorin, Chlorambucil, Chloraminophene, Ecloril, Leukeran, Leukoran, Linfolysin.

White or white with a faint pinkish or creamy tinge crystalline powder. Almost nerastvorim in water, easily soluble in alcohol.

Like other preparations of the bis- (b-chloroethyl) -amine group, chlorobutin is an alkylating cytostatic agent; Has a depressing effect on the hematopoietic tissue and hyperplastic (tumor) tissues. The drug affects more selectively on lymphoid tissue than on granulocyte elements.

Assign chlorbutin inside with chronic lymphocytic leukemia (mainly with leukemia), lympho- and reticulosarcoma, lymphogranulomatosis, as well as in ovarian cancer.

Apply inside daily in the form of tablets. The daily dose for chronic lymphatic leukemia is from 2 to 10 mg (depending on the degree of leukocytosis). The course of treatment from 3 to 6 weeks. The total dose for the course of treatment is 200-400 mg.

With a decrease in the number of white blood cells in the blood to 25 - 20 x 10 9 / l, the patient is transferred to maintenance therapy, appointing 2-6 mg per week for a year or more.

In patients with lymphogranulomatosis without leuko- and thrombocytopenia, starting with a daily single dose of 20 mg; By the end of the course, reduce the dose to 10 mg. The amount of the drug per course is 400 - 500 mg.

Chlorbutin is also used as an immunosuppressant. A dose of 5 to 10 mg per day.

As with other bis- (b-chloroethyl) -amines, during the treatment with chlorobutin it is necessary to perform a blood test (total) and differential count of leukocytes systematically (at least 2 to 3 times per week), determination of the number of platelets, erythrocytes, hemoglobin .

In the course of treatment with chlorbutin may occur leukopenia, anemia and thrombocytopenia; When an overdose develops significant leukopenia, progressing up to pancytopenia. Reducing the number of white blood cells can continue for 10 to 12 days after drug withdrawal.

With the development of severe leukopenia, stop taking the drug, and if necessary, transfer blood or inject leukocyte and platelet mass; Prescribe stimulators of hematopoiesis, vitamins. Blood transfusions (100 - 125 ml once a week) are recommended during the course of treatment.

Persons previously treated with other cytostatic drugs or who underwent radiation therapy, chlorbutin is prescribed not earlier than 1, 5 -2 months after the end of the previous treatment, provided there is no pronounced leukopenia, thrombocytopenia and anemia. The drug is prescribed, starting with small doses.

The drug is contraindicated in severe liver and kidney diseases, acute gastrointestinal diseases, immediately after the application of other cytotoxic drugs and radiation therapy, with severe leukopenia, thrombocytopenia and anemia associated with malignant development.