Description of the drug: Sarcolysin (Sarcolysinum)

SARCOLYSIN (Sarcolysinum).

D, L-a-Amino-b- [p-bis (b-chloro-ethyl) -aminophenyl] -propionic acid hydrochloride.

Synonyms: Racemelphalanum, Sarcoclorin (Foreign preparation Melphalan is the left isomer corresponding to sarcolysin [L-parabis (in-chloroethyl) -aminophenylalamine]).

White or slightly yellowish powder. Easily soluble in water when heated, soluble in dilute acids and alkalis.

Sarcolysin is a derivative of the bis (b-chloroethyl) -amine and the amino acids of phenylalanine. Like other drugs of this kind, sarcolysin has alkylating properties and suppresses the development of hyperplastic tissues.

Applied for the treatment of testicular semenoma (especially in the presence of metastases), reticulosarcoma, malignant angioendothelioma, Ewing tumor, myeloma.

In combination with colchamine (see) sarcolysin is sometimes used also for cancer of the esophagus and stomach.

The drug is prescribed inside (after eating) and intravenously, also injected into the cavity.

For oral use in tablets, 0.01 g (10 mg), for injections - in dry form in hermetically sealed bottles containing 0.02 and 0.04 g (20 and 40 mg) of the drug. To obtain a solution, 10 to 20 ml of isotonic sodium chloride solution is introduced into the vial; To accelerate the dissolution, the vial is heated in water to + 60 - 70 ° C.

Inside or intravenously prescribe the drug once a week. A single dose for an adult with a body weight of 60 to 70 kg is 40 to 50 mg; For patients with a body weight of 50 kg or less - at a rate of 0.5 to 0.7 mg / kg. In the first two administrations, 50 mg are given, then 30 mg each. Children are also prescribed at a rate of 0.5 to 0.7 mg / kg.

The course of treatment lasts 4 - 7 weeks. With metastases of tumors in serous membranes with effusion into the abdominal or pleural cavity, a solution of sarcolysin in the cavity can be administered.

In the abdominal cavity injected from 40 to 100 mg, dissolved in 20 - 50 ml isotonic sodium chloride solution, once a week; In the pleural cavity - 20 - 80 mg, dissolved in 10 - 20 ml isotonic sodium chloride solution, also once a week.

Before the introduction of the sarcolysin solution, the exudate is removed in the cavity, then injected for anesthesia with 60 to 70 ml of 1% novocaine solution, after which the trocar is removed from the abdominal cavity or the needle from the pleural cavity, the patient is given a prone position and a freshly prepared sarcolysin solution is administered 10 minutes later. The course of treatment usually 4 - 5 injections.

Often through 2 - 3 injections, resorption or a decrease in the amount of exudate occurs; Injections; However, continue. Introduce a solution of sarcolysin through a needle with a diameter of 0.3 - 0.5 ml; Preliminary (for 10 minutes) 100-120 ml of 1% solution of novocaine are injected. In total, 0.16 to 0.2 g (160 to 200 mg) of sarcolysine is used per course.

Sarcolysine can also be used for regional chemotherapy; With perfusion of tumors of extremities with the use of extracorporeal circulation apply the drug in a dose of 25 - 40 mg per 1 cm of tissues of the perfused area.