Medication Description: Sarcolysin (Sarcolysinum)
D, L-a-Amino-b- [p-bis- (b-chloro-ethyl) -aminophenyl] propionic acid hydrochloride.
Synonyms: Racemelphalanum, Sarcoclorin (The foreign drug Melphalan is the left isomer corresponding to sarcolysin [L-parabis- (b-chloroethyl) -aminophenylamine]).
White or slightly yellow powder. Easily soluble in water when heated, soluble in diluted acids and alkalis.
Sarcolysin is a derivative of bis- (b-chloroethyl) -amine and the amino acid phenylalanine. Like other drugs of this kind, sarkolizin has alkylating properties and inhibits the development of hyperplastic tissues.
Used for the treatment of seminoma of the testicle (especially in the presence of metastases), reticulosarcoma, malignant angioendothelioma, Ewing tumor, myeloma.
In combination with kolkhaminom (see) sarkolizin sometimes used also for cancer of the esophagus and stomach.
The drug is prescribed inside (after eating) and intravenously, also injected into the cavity.
Available for oral administration in tablets of 0.01 g (10 mg), for injection - in dry form in hermetically sealed vials containing 0.02 and 0.04 g (20 and 40 mg) of the drug. To obtain a solution injected into the vial 10 - 20 ml of isotonic sodium chloride solution; to accelerate the dissolution of the bottle is heated in water to + 60 - 70 C.
Inside or intravenously, the drug is prescribed once a week. A single dose for an adult weighing 60–70 kg is 40–50 mg; for patients with a body weight of 50 kg or less - at the rate of 0.5-0.7 mg / kg. In the first two doses give 50 mg, then - 30 mg. Children are also prescribed at the rate of 0.5-0.7 mg / kg.
The course of treatment lasts 4 - 7 weeks. For tumor metastases, a solution of sarcolysin in the cavity can be injected into the serous membranes with effusion into the abdominal or pleural cavity.
From 40 to 100 mg, dissolved in 20-50 ml of isotonic sodium chloride solution, are injected into the abdominal cavity once a week; in the pleural cavity - 20 - 80 mg, dissolved in 10 - 20 ml of isotonic sodium chloride solution, also 1 time per week.
Before the sarcolysin solution is introduced into the cavity, the exudate is removed, then 60 to 70 ml of 1% novocaine solution is injected for anesthesia, then, without removing the trocar from the abdominal cavity or needle from the pleural cavity, give the patient a lying position and after 10 minutes a freshly prepared sarcolysin solution is injected. The course of treatment is usually 4 to 5 injections.
Often after 2 - 3 injections, resorption or reduction of the exudate occurs; injections; however, continue. Enter the sarcolysin solution through a needle with a diameter of 0.3-0.5 ml; 100-120 ml of a 1% solution of novocaine are injected (for 10 minutes). A total of 0.16-0.2 g (160-200 mg) of sarcolysin is applied to the course.
Sarcolysin can also be used for regional chemotherapy; for perfusion of tumors of the extremities using extracorporeal blood circulation, the preparation is used in a dose of 25-40 mg per 1 cm of tissue in the perfused area.