Description of the medicine: Spirobromin (Spirobrominum)

SPIROBROMIN (Spirobrominum).

N, N "- bis - (b - Bromopropionyl) - N ', N" - dispyropiperazinium dichloride.

Synonyms: Dibrospidium chloride, Dibrospidii chloridum.

White or almost white crystalline powder; Easily soluble in water. Almost insoluble in alcohol.

The chemical structure has elements of similarity to prospidin.

Applied in acute leukemia (mainly in combination with other chemotherapeutic anti-tumor agents), with malignant lymphomas, laryngeal cancer, cutaneous reticuloses and some other oncological diseases. Can be used in combination with radiotherapy and surgical interventions.

Produced in the form of spirobromin lyophilized for injection of 0.1 (Spirobrominum lyophilisatum 0.1 pro injectionibus) - a white or almost white porous mass or powder. Enter intravenously or intramuscularly. Solutions are prepared immediately before the introduction of isotonic sodium chloride solution.

When acute leukemia is used in combination with cyclophosphamide, carminomycin, vincristine or other antitumor drugs. A dose of 200 800 mg per day (an average of 500 mg per day). If the daily dose does not exceed 500 mg, injected once; At high doses administered in 2 divided doses. The course of treatment is 7 - 14 days. Spend at least 2 courses with an interval of 10 days.

With malignant lymphomas, larynx cancer, cutaneous reticuloses, 500 mg daily are prescribed for 10 to 30 days. With the therapeutic effect, repeat courses are carried out after 1, 5 - 2 months.

When using the drug, paresthesia (in the face area, etc.) is possible. With pronounced paresthesia, reduce the dose or drug is canceled. Sometimes leukopenia, thrombocytopenia, pain in the heart area are possible.

The drug is contraindicated in the terminal stages of the disease, with severe liver, kidney, cardiovascular system, with severe leukopenia and thrombocytopenia.

Form release: in ampoules with a capacity of 5 ml with a content of 0.1 g of the drug.

Storage: List A. In the dark place.