Description of the medicine: Spirobromin (Spirobrominum)
N, N "- bis - (b - Bromopropionyl) - N ', N" - dispipiperazinium dichloride.
Synonyms: Dibrospidium chloride, Dibrospidii chloridum.
White or almost white crystalline powder; easily soluble in water. practically insoluble in alcohol.
The chemical structure has elements similar to prospidine.
It is used for acute leukemia (mainly in combination with other chemotherapeutic antitumor agents), for malignant lymphomas, laryngeal cancer, skin reticulosis and some other oncological diseases. It can be used in combination with radiation therapy and surgical interventions.
It is available in the form of lyophilized spirobromine for injection at 0.1 (Spirobrominum lyophilisatum 0.1 pro injectionibus) - a white or almost white porous mass or powder. Enter intravenously or intramuscularly. Solutions are prepared immediately before administration of sodium chloride in an isotonic solution.
In acute leukemia, it is used in combination with cyclophosphamide, carminomycin, vincristine or other antitumor drugs. Dose 200 800 mg per day (average 500 mg per day). If the daily dose does not exceed 500 mg, administered once; at large doses, administered in 2 doses in equal doses. The course of treatment is 7-14 days. Conduct at least 2 courses with an interval of 10 days.
For malignant lymphomas, cancer of the larynx, skin reticulosis, 500 mg is prescribed daily for 10 to 30 days. With the therapeutic effect, repeated courses are carried out after 1, 5 - 2 months.
When using the drug, paresthesia is possible (in the face, etc.). With severe paresthesia, the dose is reduced or the drug is canceled. Sometimes leukopenia, thrombocytopenia, pain in the heart are possible.
The drug is contraindicated in the terminal stages of the disease, with severe diseases of the liver, kidneys, cardiovascular system, with severe leukopenia and thrombocytopenia.
Release form: in ampoules with a capacity of 5 ml with the content of 0.1 g of drug.
Storage: List A. In the dark place.