Medication Description: Spirobromin (Spirobrominum)
N, N "- bis - (b - Brompropionyl) - N ', N" - dispiropiperazinium dichloride.
Synonyms: Dibrospidium chloride, Dibrospidii chloridum.
White or almost white crystalline powder; easily soluble in water. practically insoluble in alcohol.
The chemical structure has elements of similarity with prospidin.
Applied with acute leukemia (mainly in combination with other chemotherapeutic anticancer agents), with malignant lymphomas, laryngeal cancer, skin reticulosis and some other oncological diseases. Can be used in combination with radiotherapy and surgery.
Available in the form of lyophilized spirobromin for injection 0.1 (Spirobrominum lyophilisatum 0.1 pro injectionibus) - white or almost white porous mass or powder. Enter intravenously or intramuscularly. Solutions are prepared immediately before the introduction of an isotonic solution of sodium chloride.
In acute leukemia, used in combination with cyclophosphamide, carminomycin, vincristine, or other anticancer drugs. Dose 200 800 mg per day (on average 500 mg per day). If the daily dose does not exceed 500 mg, administered once; with large doses, administered in 2 doses in equal doses. The course of treatment is 7-14 days. Spend at least 2 courses with an interval of 10 days.
For malignant lymphomas, laryngeal cancer, skin reticulosis, 500 mg daily is prescribed for 10 to 30 days. When the therapeutic effect is repeated courses after 1, 5 - 2 months.
With the use of the drug may paresthesia (in the face, etc.). In severe paresthesia, reduce the dose or cancel the drug. Sometimes leukopenia, thrombocytopenia, pain in the heart area are possible.
The drug is contraindicated in the terminal stages of the disease, with severe diseases of the liver, kidneys, cardiovascular system, with severe leukopenia and thrombocytopenia.
Product: in 5 ml ampoules with a content of 0.1 g of the drug.
Storage: List A. In the dark spot.