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Description of the medicine: Dipinum (Dipinum)

DIPIN (Dipinum). 1, 4-bis- [N, N'-di (Ethylene) -phosphamide] -piperazine.

White crystalline powder. Soluble in water, easily - in alcohol. Aqueous solutions are easily hydrolyzed.

Deepin, like other compounds containing ethylenimine groups (thiophosphamide, etc.), inhibits the development of proliferating tissue, including malignant tissue.

They are used for the treatment of chronic lymphocytic leukemia, which occur with tumor-like growths, with a content of leukocytes in the blood above 75 x 10 9 / l and in the presence of resistance to radiation therapy. There are data on the effectiveness of dipin in laryngeal cancer, metastases of hypernephroma and some other tumor processes.

Enter intravenously or intramuscularly.

The drug is released as a sterile lyophilized powder or a porous mass of white or slightly yellowish tinge in hermetically sealed bottles of 0.02 g (20 mg). Solutions are prepared ex tempore in 2 or 4 ml of isotonic sodium chloride solution (obtain respectively 1% or 0.5% solution).

In chronic lymphatic leukemia begins with the administration of 5 mg (1 ml of a 0.5% solution) daily or 10 mg (2 ml of 0.5% solution) every other day. In the future, the intervals between injections can be extended to 2 - 3 days (depending on the effect and results of hematological studies).

With good tolerability and in cases where 4 to 5 injections of the drug at a dose of 5 to 10 mg do not lead to a decrease in the number of leukocytes, the dose can be increased to 15 mg (3 ml of a 0.5% solution). With a very rapid decrease in the number of leukocytes, the drug is administered at a dose of 10 to 5 mg, with increasing intervals between injections to 3 to 5 days. The total dose depends on the clinical effect and the effect on the hematopoietic system; Usually the total amount of the drug on the course of treatment can be brought to 0.2 g (200 mg).

Treatment with the drug should be carried out under careful hematological control: every 2 to 3 days, the content of leukocytes and platelets in the peripheral blood is determined, and a general blood test is performed on a weekly basis. With a decrease in the number of white blood cells to 30 x 10 9 / l, treatment with dipin is stopped, taking into account the aftereffect of the drug, continuing until 3 to 4 weeks. If the number of white blood cells soon increases again, you can resume treatment with dipin to fix the therapeutic effect, appointing 5 mg per injection.

Treatment with dipin is desirable to combine with the use of corticoid drugs and restorative therapy.

In case of severe anemia, the purpose of dipin is combined with blood transfusion (erythrocyte mass).

With metastases of hypernephroma, dipin is administered at a dose of 30 mg (3 ml of a 1% solution) after 3 days or 40 mg (4 ml of 1% solution) after 4 days. With a slow and insignificant decrease in the number of leukocytes and platelets, the procedure is repeated 3 times, then the dose is gradually reduced to 20 - 5 mg. With a sharp decrease in the number of leukocytes and platelets, the dose is reduced to 20 to 10 mg after the first injection and the intervals between administrations are increased. With a reduction in the number of leukocytes to 3, 5 x 10 9 / l and platelets to 100 x 10 9 / l, the treatment is stopped.