Description medications: Mielosan (Myelosanum)
Methylsulfonic bis-ester of butanediol-1, 4.
Synonyms: busulfan, Busulfan, Busulphan, Citosulfan, Leukosulfan , Mielucin, Misulban, Mitostan, Myeleukon, Mylecytan, Myleran, Mysulban, Sulfabutin and others.
The white crystalline powder. Very slightly soluble in water and alcohol,
It has a depressing effect on the myeloid tissue. Selectively inhibits granulocytopoiesis and gives antileukemic effect in chronic myeloid leukemia. Effect of the drug is manifested primarily in reducing the number of immature granulocytes.
Applied with chronic myeloid leukemia (leukaemic form).
Assign into 2 mg (0.002 g) 1 - 3 times a day.
During exacerbation of chronic myeloid leukemia, accompanied by moderate splenomegaly and an increase in the number of white blood cells up to 200 x 10 9 / L, administered 4 - 6 mg per day (1 - 3 admission). When pronounced splenomegaly and leukocytosis (leukocytes than 200 x 10 9 / L), the daily dose was increased to 8 - 10 mg of (2 - 3 doses), and then decreased to 6 - 4 mg, the number of leukocytes becomes less than 200 x 10 9 / l. By reducing the number of leukocytes to 50 x 10 9 - 40 x 10 9 / L, the daily dose should not exceed 4 mg. The treatment ends with remission, which usually occurs no earlier than 3 - 5 weeks after starting treatment.
Higher doses for adults inside: single 0.006 g (6 mg), 0.01 g daily (10 mg).
When myeloid leukemia relapse to repeat courses, the dose is adjusted to the number of leukocytes in peripheral blood and the disease.
By mielosanu arises stability and effectiveness of the treatment decreases with time. To achieve the desired effect in these cases, an increase in the dose required, which, however, it is unsafe. Increasing the dose should be with great care, and the need to systematically examine the blood during and after treatment.
In case of overdose mielosana a depressing effect on the blood can spread to mature granulocytes and platelets to the development of granulocytopenia and thrombocytopenia with hemorrhage. Blood tests should be performed at least once every 5 days, and with a decrease in the number of leukocytes up to 50 x 10 9 / L -40 x 10 9 / l - every 2 days. During the clinical and hematological remission blood tests carried out at least 2 times a month.
In severe anemia shows a blood transfusion, or red blood cells, with inhibition leykopoeza - leykopoeza stimulators, stimulating blood transfusion amounts buffy weight; administered ascorbic acid, vitamin E, and others.
In the treatment can be observed mielosanom dystonia, temporary amenorrhea, skin pigmentation, inhibition of sexual function in men.
The drug is contraindicated in acute and subacute leukemias, an exacerbation of chronic myeloid leukemia, if it takes place according to the type of acute leukemia, and when aleukemic subleukemic forms of chronic leukemia; with severe thrombocytopenia.
Product: pills to 0,002 grams (2 mg).
Storage: List A. In the dark spot.