Medication Description: Mercaptopurin (Mercaptopurinum)
MERCAPTOPURIN (Mercaptopurinum). 6-Mercaptopurine (monohydrate).
Synonyms: Leukerin, Leukerin, Leupurin, Purinethol, Ismipur, Leukerin, Leupurin, Mercalenein, Mercaptopurine, Mercapurin, Mycaptine, Oncomercaptopurina, Purinethol.
Yellow crystalline powder. Practically insoluble in water and alcohol, soluble in hot water, in alkali solutions.
Mercaptopurine is an antimetabolite of purines. By structure, 6-mercaptopurine is close to adenine (6-aminopurine), hypoxanthine (6-oxypurine), guanine (2-amino-6-oxypurine).
Being a structural analogue - an antimetabolite of these compounds that are part of nucleic acids (DNA, RNA), mercaptopurine violates the biosynthesis of nucleotides, inhibits the growth of proliferating tissues and has a cytotoxic effect.
Mercaptopurine is used in the treatment of acute (subacute) leukemia, as well as in exacerbations of chronic myeloid leukemia, occurring in the type of acute leukemia. It is also used in chorionepithelioma of the uterus (usually in combination with methotrexate) and in the treatment of reticulosis.
The drug can be used in patients with acute leukemia in cases of developed resistance to antifolia drugs - methotrexate,
Assign inside by 2, 0- 2, 5 mg / kg in one or two doses. If the therapeutic effect does not occur, the daily dose is increased to 5 mg / kg (not more).
Mercaptopurine, like other cytotoxic drugs, has immunosuppressive activity and is used in some cases (in doses of 50–150 mg per day) for the treatment of autoimmune diseases: rheumatoid arthritis, chronic hepatitis, lupus nephritis, etc. (see Immunodepression drugs).
Mercaptopurine is also used to treat psoriasis. Assign an adult to 0.05 g 2 - 3 times a day in 10-day cycles with intervals of 3 days. Just spend 3 to 4 cycles. Treatment usually gives a temporary effect.
When using mercaptopurine, side effects can occur: general weakness, lesions of the oral mucosa, dyspeptic symptoms with vomiting and diarrhea. Like other cytotoxic drugs, mercaptopurine can cause leukemia and thrombocytopenia.
Treatment with mercaptopurine should be carried out under careful clinical and hematological control.
When pronounced phenomena of hematopoietic depression, the drug is canceled and hemostimulating therapy is prescribed. During and after the end of treatment (for 2 weeks) at least 2 times a week, monitor the parameters of peripheral blood and bone marrow hematopoiesis.
Necessary to monitor the functions of the liver and kidneys.
Mercaptopurine is contraindicated in leukopenia (leukocytes less than 3 x 10 / l of blood), thrombocytopenia (platelets less than 100 x 109 / l), in diseases of the liver, kidneys, in pregnancy.
Form release: pills to 0.05 g.
Storage; List A. In a well-closed container.