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Description medications: Mercaptopurine (Mercaptopurinum)

Mercaptopurine (Mercaptopurinum). 6-Mercaptopurine (monohydrate).

Synonyms: Leykerin, Leukerin, Leupurin, Purinethol, Ismipur, Leukerin, Leupurin, Mercalenein , Mercaptopurine, Mercapurin, Mycaptine, Oncomercaptopurina, Purinethol.

Yellow crystalline powder. Practically insoluble in water and alcohol, soluble in hot water, in alkaline solutions.

Mercaptopurine is an antimetabolite purines. According to the structure of 6-mercaptopurine close to adenine (6-aminopurine), hypoxanthine (6-oksipurin), guanine (2-amino-6-oksipurin).

As a structural analogue - an antimetabolite of these compounds that make up nucleic acids (DNA, RNA), mercaptopurine violates the biosynthesis of nucleotides, inhibits the growth of proliferating tissues and cytotoxic influence.

Mercaptopurine used in the treatment of acute (subacute) leukemia and acute exacerbations of chronic myeloid leukemia, flowing type of acute leukemia. Furthermore, when used horionepitelioma uterus (usually in combination with MTX) in the treatment Reticulose.

The drug can be used in patients with acute leukemia in cases of resistance to antifolievym drugs - methotrexate,

Assign into 2, 0 2, 5 mg / kg in one or two steps. If the therapeutic effect is attained, the daily dose was increased to 5 mg / kg (maximum).

Mercaptopurine as other cytostatic drugs has immunosuppressive activity and is used in some cases (in doses of 50 - 150 mg per day) for the treatment of autoimmune diseases: rheumatoid arthritis, chronic hepatitis, lupus nephritis, etc. (refer Immunosuppressive drugs.)..

Applied also mercaptopurine for the treatment of psoriasis. Designate an adult to 0.05 g of 2 - 3 times a day, 10-day cycles with intervals of 3 days. Total spend 3 - 4 cycles. Treatment usually gives a temporary effect.

When using mercaptopurine may experience side effects: weakness, lesions of the mucous membranes of the mouth, dyspepsia with vomiting and diarrhea. Like other cytotoxic drugs, mercaptopurine can cause thrombocytopenia leykoi.

mercaptopurine treatment should be under close clinical and haematological control.

At sharply expressed depression phenomena hematopoiesis, drug overturned and prescribe hemostimulating therapy. During and after treatment (within 2 weeks) at least 2 times a week, make control peripheral blood and bone marrow hematopoiesis.

Requires control over the functions of the liver and kidneys.

Mercaptopurine is contraindicated in leukopenia (leukocytes less than 3 x 10 / liter of blood), thrombocytopenia (platelet counts less than 100 x 109 / l), liver diseases, kidney disease, pregnancy.

Product: pills to 0.05 g

Storage; List A. In a well-closed container.