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Description medications: Apodorm

Nitrazepam (Nitrazepamum). 7-Nitro-2, 3-dihydro-5-phenyl-1H-1, 4-benzodiazepin-2-one:

Synonyms: Mogadon, Neozepam, radedorm, Eunoktin, Apodorm, Benzalin, Calsmin, Dormicum , Dumolid, Epibenzalin, Epinelbon, Eunoctin, Hipnax, Hipsal, Insomin, Livetan, Magadon, Mitidin, Mogadan, Mogadon, Nelbon, Neozepam, Nitrenpax, Nitrodiazepam, Pacidrim, Pacisyn, Radedorm, Serenex, Somitran, Sonipam, Sonnolin and others.

Light yellow or light yellow with greenish white crystalline powder. Practically insoluble in water, slightly soluble in alcohol and ether.

On chemical structure and pharmacological properties similar to nitrazepam tranquilizer benzodiazepine group (See.) The distinctive feature of stukturnoy nitrazepama is the presence of the nitro group (NO) in the 7-position of the benzodiazepine nucleus.

Like other derivatives benzodiapezina, nitrazepam has tranquilizing, anxiolytic (antianxiety), muscle relaxant (muscle-relaxing), an anticonvulsant effect, depresses conditioned reflexes, suppresses polisinapticheskie spinal reflexes. Nitrazepama distinctive feature is its marked sedative effect.

Influenced nitrazepama increase the depth and duration of sleep. Sleep typically occurs within 45 minutes. after drug administration and lasts for 6-8 hours.

Apply nitrazepam with sleep disorders of various kinds, as well as in the neuroses of different genesis and psychopaths with a predominance of anxiety. In combination with other psychotropic drug agents prescribed to patients with schizophrenia, manic-depressive psychosis (in manic and hypomanic phases), when certain organic lesions of the central nervous system (trauma disorders of cerebral circulation), as well as for the relief of withdrawal symptoms in chronic alcoholism.

How calming and anticonvulsant nitrazepam in combination with an anticonvulsant prescribed to patients with epilepsy. The drug is used in anesthetic practice for sedation in the postoperative period.

Take into nitrazepam; as a sleep aid - for half an hour so sleep. Single dose for adults is 0,005 - 0,01 g (5 to 10 mg); for children under 1 year of 0.00125 - 0.0025 g (1, 2 25, 5 mg), 1 - 5 years 0025 - 0.005 g (2, 5 - 5 mg); 6 - 14 years - 0,005 grams (5 mg). Elderly appoint 0.0025 - 0.005 g (2, 5 - 5 mg). The maximum single dose as a sleep aid for adults is 0.02 g (20 mg). As an anxiolytic and anticonvulsant nitrazepam is used 2 to 3 times per day to 0,005 - 0,01 g (5 - 10 mg); if necessary, as a single dose anticonvulsant can be improved. Higher daily doses of 0.03 g (30 mg). In exchange treatment duration nitrazepama application is 30 - 45 days. In some cases, the duration of treatment can be increased.

When using nitrazepama, oso6enno in large doses, can daytime sleepiness, feeling of weakness, ataxia, incoordination, headache, stupor, dizziness, in rare cases, nausea, tachycardia, rash, skin and allergic reactions.