Medication Description: Vinblastine (Vinblastinum)
Alkaloid contained in the plant of periwinkle pink (Vinca rosea L.), as well as in the plant carantus pink (Catharanthus roseus L.).
Available in the form of sulfate.
It refers to the alkaloids of the indole series.
Synonyms: Velbe, Cytoblastin, Blastovin, Cytoblastine, Exal, Periblastine, Velban, Velbe, Vinblastine, Vincaleukoblastine.
Domestic name "Rosevin" (Rosevinum).
White or white with a cream tinge crystalline powder. Hygroscopic, sensitive to light. Easily soluble in water, practically insoluble in alcohol.
Vinblastine is a cytostatic agent with antitumor activity.
The mechanism of antitumor action is explained by the ability of the drug to block the mitosis of cells at the metaphase stage.
Vinblastine inhibits leukopoiesis and thrombocytopoesis; does not significantly affect erythropoiesis.
Apply vipblastin (rosevin) with lymphogranulomatosis, hematosarcoma, myeloma, choriocarcinoma.
Enter the drug intravenously once a week. Before use, dissolve the contents of the vial (5 mg) in 5 ml of isotonic sodium chloride solution. The initial dose is 0.025 mg / kg, then the dose is gradually increased (monitor the number of leukocytes and platelets in the blood) to 0.15 - 0.3 mg / kg. Course dose 100 - 120 mg. In the absence of effect, the use of the drug is stopped at a total dose of 50 mg. If a therapeutic effect is observed, a long-term maintenance therapy is carried out, selecting the dose, which, with regular use, does not reduce the level of leukocytes in the blood below 3 x 10 9 / l. The drug is administered 1 time in 2 to 4 weeks. In case of deterioration of the patient's condition, reduce the intervals between injections.
Vinblastine (rozevin) is widely used in the complex chemotherapy of tumors in combination with other anticancer drugs.
The use of the drug may cause general weakness, loss of appetite, nausea, vomiting, abdominal pain, paresthesia, albuminuria, jaundice, stomatitis, urticaria, depression, alopecia, phlebitis.
The treatment is carried out under the systematic control of the blood picture; analyzes are carried out 1 time in 3 days. With a decrease in the number of leukocytes to 3 x 10 9 / l and platelets to 100 x 10 9 / l, the use of the drug is stopped. If necessary, prescribe a transfusion of blood or its uniform elements, antibiotics.
The drug is contraindicated in the oppression of the hematopoietic system, acute gastrointestinal diseases and gastric ulcer and duodenal ulcer, in the terminal stage of the disease.
It is necessary to be careful not to get solutions under the skin due to strong irritation of tissues.
Product form: in lyophilized form (porous mass of white or white with a slightly yellowish tint) in ampoules and vials of 0.005 g (5 mg).
Storage: List A. In the dark place at a temperature of not more than + 10 C.