Description of the medicine: Vinblastin (Vinblastinum)
The alkaloid contained in the plant pink periwinkle (Vinca rosea L.), as well as in the plant catharanthus pink (Catharanthus roseus L.).
Available in the form of sulfate.
Refers to alkaloids of the indole series.
Synonyms: Velbe, Cytoblastin, Blastovin, Cytoblastine, Exal, Periblastine, Velban, Velbe, Vinblastine, Vincaleukoblastine.
Domestic name "Rosevinum" (Rosevinum).
Fine crystalline powder white or creamy white. Hygroscopic, sensitive to light. Easily soluble in water, practically insoluble in alcohol.
Vinblastine is a cytostatic substance with antitumor activity.
The antitumor action mechanism is explained by the ability of the drug to block cell mitosis at the metaphase stage.
Vinblastine inhibits leukopoiesis and thrombocytopoiesis; does not significantly affect erythropoiesis.
Vibblastine (rosewin) is used for lymphogranulomatosis, hematosarcoma, myeloma, choriocarcinoma.
The drug is administered intravenously once a week. Before use, dissolve the contents of the vial (5 mg) in 5 ml of isotonic sodium chloride solution. The initial dose is 0.025 mg / kg, then the dose is gradually increased (the number of leukocytes and platelets in the blood is monitored) to 0.15 - 0.3 mg / kg. The course dose is 100 - 120 mg. In the absence of effect, the use of the drug is stopped at a total dose of 50 mg. If a therapeutic effect is observed, prolonged maintenance therapy is carried out, selecting a dose that, with regular use, does not reduce the level of leukocytes in the blood below 3 x 10 9 / L. The drug is administered 1 time in 2 to 4 weeks. If the patient worsens, the intervals between administrations are reduced.
Vinblastine (rosevin) is widely used in the complex chemotherapy of tumors in combination with other antitumor drugs.
When using the drug, general weakness, loss of appetite, nausea, vomiting, abdominal pain, paresthesia, albuminuria, jaundice, stomatitis, urticaria, depression, alopecia, phlebitis are possible.
Treatment is carried out under the systematic control of a blood picture; analyzes are carried out 1 time in 3 days. With a decrease in the number of leukocytes to 3 x 10 9 / l and platelets to 100 x 10 9 / l, the use of the drug is stopped. If necessary, prescribe a transfusion of blood or its shaped elements, antibiotics.
The drug is contraindicated in suppression of the hematopoietic system, acute gastrointestinal diseases and peptic ulcer of the stomach and duodenum, in the terminal stage of the disease.
You should be careful not to get solutions under the skin due to severe tissue irritation.
Release form: in the lyophilized form (porous mass of white or white with a slightly yellowish shade of color) in ampoules and bottles of 0.005 g (5 mg).
Storage: List A. In the dark place at a temperature of no higher than + 10 C.