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Description medications: kolhamina (Colchaminum)

Kolhamina (Colchaminum).

Kolhamina is one of the alkaloids isolated from colchicum corms magnificent (Colchicum Speciosum Stev.), Sem. lily (Liliaceae) second alkaloid contained in these corms is colchicine (Colchicinum).

Both alkaloids have similar structure. Colchicine is (S) N- (5, 6, 7, 9-tetrahydro - 1, 2, 3, 10-tetramethoxy-9-oxobenzo [a] heptalene-7-yl) -acetamide and kolhamin substituted acetamido group instead of (NH -COCH 3) aminomethyl (NH - CHz).

Synonyms colchicine: Artrichine, Colchiquim, Colchisol, Colcin, Colgout, Coluric, Novolchine.

Synonyms kolhamina: Omain, Coclemid, Demecolcine, Omain.

Both alkaloids are white or white with a yellowish tinge fine crystalline powder. Have similar pharmacological properties, however, it is less toxic kolhamin (7 - 8 times). Both drugs have antimitotic activity have karioklasticheskoe action affect depressing leiko- and lymphopoiesis.

Kolhamin specialists drew attention mainly as an agent for external application (as an ointment) in malignant skin diseases.

Kolhamin also proposed to use, especially in combination with derivatives of bis- b chloroethyl) - amine (sarcolysine), for the treatment of esophageal cancer. For this purpose kolhamin administered orally in form of tablets of 6 - 10 mg (0.006 - 0.01 g) of 2 - 3 times a day, the total course dose 50 - 110 mg.

Such use kolhamina requires careful medical supervision and hematological control. At the level of white blood cells below 3 x 10 9 / l and platelet count below 100 x 10 9 / l stopped taking the drug to restore blood picture.

When receiving kolhamina may be nausea and vomiting. In case of overdose possible strong oppression blood. Methods of prevention and treatment of these complications are the same as the application of other cytotoxic drugs.

There are also temporary diarrhea and alopecia. When the blood in the vomit and tarry stool stop treatment and spend hemostatic therapy. In the course of treatment should be carried out periodically study fecal occult blood.

Application kolhamina (and its combination with other anticancer drugs) is contraindicated in esophageal cancer at the emerging signs of perforation in the bronchi and in the presence of the perforation; with a pronounced inhibition of bone marrow hematopoiesis (white blood cell count below 4 x 10 9 / L, platelets less than 10 x 100 / L), as well as anemia.

Method of issuance: pills to 0,002 grams (2 mg); Ointment 0.5%.

Storage: List A. In a cool, dark place.

Colchicine, due to the presence along with the ability to antimitotic activity inhibit the formation of amyloid fibrils block amyloidosis implement uricosuric and anti proposed primarily for the treatment of gout and periodic disease.

Colchicine Assign inside a pill.