Description of the medicine: Podophyllinum

PODOFILLIN (Podophyllinum).

Synonym: Neorondex, Neorondexum

A mixture of natural compounds obtained from rhizomes with the roots of the podophyllum of the thyroid (Podophyllum peltatum L.), family. Barberry (Berberidaceae).

Contains podophyllotoxin (at least 40%), a - and b-peltatins.

Amorphous powder or mass from yellow-brown to yellow-green color with a specific odor.

Extracts from the roots of the podophyll have long been used in folk medicine as laxatives, vomiting and anthelmintics. Later it was established that they possess cytostatic activity and block mitosis at the stage of metaphase, reminiscent of the action of colchicine.

As an antineoplastic agent, podophylline has found application in the treatment of papillomas - papillomatosis of the larynx and papillomas of the bladder.

There are also data on the use of pofillina in the treatment of lymphangiomas.

With papillomatosis of the larynx in children, first remove the papilloma surgically, and then 1 time in 2 days, lubricate the mucosa at the site of removal of 15% alcohol solution of podophyllin. The course of treatment 14 16 lubrication. For children under 1 year, use the drug with caution. In adults, lubricate the larynx with 30% alcohol solution of podophyllin 10 times, then remove the papillomas and relubricate 20 times. In the absence of inflammatory reaction, lubricate daily, in the presence of inflammatory reaction - 1 time in 2 - 3 days.

A suspension of podophyllin is injected into the bladder for small typical and atypical papillary fibroepitheliomas. In combination with electrocoagulation, podophyllin is used to prevent relapses. In the bladder, 1%, 4%, 8% or 12% of the suspension of podophyllinum in vaseline oil is injected into the bladder in an amount of 100 ml for 30-40 min or 1-2 hours with a weekly break. After infusion, the patient should lie for a while on one, then on the other side.

When applying podophylline, there is a burning sensation in the bladder, which passes after removing the drug.

If, when lubricating the larynx, nausea, vomiting, gastrointestinal upset occur, the drug is discontinued.

Product: powder of 100 or 200 g in cans of orange glass.

Storage: List A. In dry, the dark place at room temperature.

Note.

When working with the drug (preparation of solutions, suspensions, etc.), in order to avoid it falling on the conjunctiva should work in glasses.

On the basis of active substance pofillina - podophyllotoxin, semi-synthetic glycosides - Etoposide (Etoposide) and Teniposide (Teniposide), effective for some types of tumors - were obtained. Etoposide found practical application as an antitumor agent. Teniposide is in the stage of further study.