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Description medications: chlorotrianisene (Chlortrianisenum)

Chlorotrianisene (Chlortrianisenum). 1, 1, 2-Trianizil-2-chloroethylene.

Synonyms: Chlorotrianisen, Chlorotrisin, Chlortrianisoestrolum, Hormonisene , Merbentul, Metace, TACE, Trianisoestrol and others.

The white crystalline powder and odorless. Practically insoluble in water, soluble in alcohol difficult.

Chlorotrianisene is a synthetic drug with estrogenic activity. It is effective when taken orally, low toxicity. Compared with other synthetic estrogenic drugs (sinestrol, diethylstilbestrol), a longer-acting. Applied primarily in the treatment of patients with prostate cancer.

Assign the interior of 0,012 g (= 12 mg 1 tablet) 2 - 3 times a day. Treatment is carried out for a long time. Metastases apply additional prednisolone: ​​the first 3 days given by 0.012 g (12 mg) three times a day for 4 - 5 th day - 0,012 g, 2 times a day, then for 7 days - 0.012 grams per day and starting from the 13th day - 0,005 grams (5 mg) per day for 40 days. These courses are held 1 - 2 times a year.

When breast cancer is prescribed 48 mg per day (1 tablet 4 times). Assign only patients in the late menopause and patients with hysterectomy (because of possible hyperplasia of the uterine lining).

Higher doses for adults inside: single 0,012 grams daily 0,048 g

Chlorotrianisene generally well tolerated. It does not cause nausea, vomiting, edema; few expressed feminizing effects (usually not observed gynecomastia); appearing sometimes swelling and pain in the breast quickly pass.

Product: tablets, containing 0,012 g (12 mg) chlorotrianisene.

Storage: List B. In the dark spot.