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Description of the medicine: Chlortrianisen (Chlortrianisenum)

CHLORTRIANISENUM (Chlortrianisenum). 1, 1, 2-Trianisyl-2-chloroethylene.

Synonyms: Chlorotrianisen, Chlorotrisin, Chlortrianisoestrolum, Hormonisene, Merbentul, Metace, TACE, Trianisoestrol, etc.

Flavourless white crystalline powder. It is practically insoluble in water, it is hardly soluble in alcohol.

Chlortrianisen is a synthetic drug with estrogenic activity. Effective when taken orally, low toxicity. Compared with other synthetic estrogenic drugs (synestrol, diethylstilbestrol), it acts longer. They are mainly used in the treatment of patients with prostate cancer.

Assign inside of 0.012 g (12 mg = 1 tablet) 2 to 3 times a day. The treatment is carried out for a long time. For metastases, prednisone is additionally used: in the first 3 days they give 0.012 g (12 mg) 3 times a day, on the 4th - 5th day - 0.012 g 2 times a day, then for 7 days - 0.012 g per day and starting from the 13th day - at 0.005 g (5 mg) per day for 40 days. Such courses are conducted 1-2 times a year.

For breast cancer, 48 mg is prescribed per day (1 tablet 4 times). Assign only to patients in late menopause and patients with a removed uterus (due to possible hyperplasia of the uterine mucosa).

Higher doses for adults inside: single 0.012 g, daily 0.048 g.

Chlorotrianisen is usually well tolerated by patients. It does not cause nausea, vomiting, edema; little feminizing effect (usually gynecomastia is not observed); sometimes swelling and pain in the mammary gland pass quickly.

Release form: tablets containing 0.012 g (12 mg) of chlortrianisen.

Storage: List B. In the dark place.