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Description of the medicine: Estracyt (Estracyt)

ESTRACYT (Estracyt).

Estradiol 3- [bis (2-chloroethyl) carbamate] 17- (dioxiphosphate).

Synonyms: Emcyt, Estramustine phosphate, etc.

By chemical structure, it is a combination of phosphoric ester of estradiol with the remainder of bis- (b-chloroethyl) -amine (see Embihin).

It is an estrogen and cytotoxic agent effective in prostate cancer. It has antigonadotropic properties. At the usual dosage does not cause severe inhibition of hematopoiesis.

Applied with advanced prostate cancer and with the ineffectiveness of hormone replacement therapy.

Assign inside and intravenously. Inside, take 1 hour before meals or 2 hours after meals, 2 to 3 capsules (280 mg per capsule) 2 times a day. Washed down with water. At the same time, you should not take milk, dairy products or preparations containing calcium.

If there is no effect within 3 to 4 weeks, treatment is stopped.

You can start treatment with intravenous injections of 0.3 g (300 mg) daily for 3 weeks, followed by taking 2 to 3 capsules 2 times a day or injecting 0.3 g 2 times a week into a vein.

It should be injected into a vein slowly over a period of 3-5 minutes (to avoid phlebitis).

A solution of estracyte can be administered as an infusion (not more than 3 hours). To do this, dissolve the contents of the ampoule in 8 ml of solvent, slightly shaking, but not allowing foaming, then dilute in 250 ml of a 5% glucose solution. The use of isotonic sodium chloride solution for this purpose is not allowed.

After intravenous administration of estracyte, a small amount of 5% glucose solution should be introduced (without removing the needle) (for washing the needle).

When using estracyte, nausea, vomiting, diarrhea, leukopenia, in rare cases of allergic reactions, pain in the heart can occur. Thromboembolism, gynecomastia are possible.

The drug is contraindicated in acute diseases of the liver and heart, thrombophlebitis.

Method of release: capsules of 0.28 g, (280 mg) in bottles of 100 capsules; 1, 5% solution in ampoules of 10 ml (150 mg per ampoule) and 3% solution in ampoules of 10 ml (300 mg per ampoule) in a package of 10 ampoules with 10 ampoules of solvent.

Storage: at a temperature of no higher than + 25 C.