Description of the medicine: Tamoxifen (Tamoxifenum)

TAMOXIFENUM (Tamoxifenum). 1- [p- [2- (Dimethylamino) ethoxy] phenyl] -trans-1, 2-diphenyl-1-butene.

Produced in the form of citrate.

Synonyms: Zitazonium, Citofen, Noltam, Nolvadex, Tamaxin, Tamofen, Tamoplex, Tamoxifen citrate, Valodex, Zitazonium and others.

The structure has elements of similarity with chlorotrianizen and clomiphen citrate (see).

The drug is considered as one of the main modern anti-estrogens.

The mechanism of anti-estrogenic action of tamoxifen and other anti-estrogens is explained by their ability to competitively bind to estrogen receptors in target organs and thus prevent the formation of the estrogen receptor complex with the endogenous ligand 17β-estradiol.

As an antitumor agent, tamoxifen is used in breast cancer in women (in the postmenopausal period), in endometrial cancer, as well as in anovulatory infertility.

Assign inside the form of tablets, with breast cancer take 20 - 40 mg 1 - 2 times a day; With endometrial cancer - 20-30 mg 1 - 2 times a day; At anovulatory infertility - 10 mg 2 times a day for 4 consecutive days, starting from the 2nd day of menstruation. With subsequent 4-day cycles, you can increase the dose to 20 - 40 mg 2 times a day.

Possible side effects: gastrointestinal disorders, dizziness, skin rash, hypercalcemia, thrombocytopenia. Moderate metrorrhagia may occur; In this case, reduce the dose. Thrombosis development was also noted. At high doses, changes in the retina of the eye can be observed.

The drug is contraindicated in pregnancy.

Form release: tablets of 0.01 g (10 mg); 0.02 g (20 mg); 0.04 g (40 mg).

Storage: in a dark place at room temperature.