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Description of the medicine: Flutamide (Flutamide)
Flutamide (Flutamide). 4'-Nitro-3'-trifluoromethyl-isobutyric anilide. Synonyms: Flucin, Flucin, Cebatrol, Drogenil, Euflex, Eulexin, Flucinom, Fugerel, Fulforel, Hibitron, Norex and others.
The drug blocks the binding of androgens (dihydrotestosterone) by cellular receptors and prevents the manifestation of the biological effects of androgens in androgen-sensitive organs, including cells in the tumor of the prostate.
Apply flutamide (niftolide) mainly for palliative treatment of advanced prostate cancer.
Assign inside the form of tablets (0.25 grams) 1 tablet 3 times a day. The drug is absorbed quickly when taken orally. The half-life is 5-6 hours. It is mainly excreted by the kidneys in the form of metabolites.
Treatment is carried out for a long time (depending on the course of the disease).
The drug is usually well tolerated. With prolonged use, gynaecomastia may develop, pain in the mammary glands. In some cases, a slight increase in the concentration of methemoglobin, which is transient, is possible.
During the treatment it is necessary to periodically examine the function of the liver. Care should be taken when prescribing the drug for people with cardiovascular disease.
The drug is also used for differential diagnosis of hypogonadism in men. To this end, appoint 10 mg / kg per day in 3 doses for 3 days with the study of excretion of gonadotropins.
The use of flutamide is contraindicated in cases of severe liver, kidney, thyroid gland diseases.
Form release: tablets (light yellow color) to 0.25 g.
Storage: at room temperature.
Close to the structure and action to niftolide, non-steroidal antiandrogen is the drug nilutamide. (Nilutamide; synonymous with anandron-Anandron) -5,5-dimethyl-3- [4-nitro-3- (trifluoromethyl) phenyl] -2,4-imidazolidinedione.
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