Description of the medicine: Flutamide (Flutamide)
Flutamide (Flutamide). 4'-Nitro-3'-trifluoromethyl-isobutyranyl. Synonyms: Flucin, Flucin, Cebatrol, Drogenil, Euflex, Eulexin, Flucinom, Fugerel, Fulforel, Hibitron, Norex, etc.
The drug blocks the binding of androgens (dihydrotestosterone) to cellular receptors and prevents the manifestation of the biological effects of androgens in androgen-sensitive organs, including prostate tumor cells.
Flutamide (niftholide) is used mainly for the palliative treatment of advanced prostate cancer.
Assign inside in the form of tablets (0.25 g), 1 tablet 3 times a day. The drug is rapidly absorbed when taken orally. The half-life is 5-6 hours. It is mainly excreted by the kidneys in the form of metabolites.
Treatment is carried out for a long time (depending on the course of the disease).
The drug is usually well tolerated. With prolonged use, the development of gynecomastia, pain in the mammary glands are possible. In some cases, a slight increase in the concentration of methemoglobin is possible, which is transient in nature.
During treatment, it is necessary to periodically examine the function of the liver. Caution should be exercised when prescribing the drug to people suffering from diseases of the cardiovascular system.
The drug is also used for the differential diagnosis of hypogonadism in men. For this purpose, 10 mg / kg per day is prescribed in 3 divided doses for 3 days with the study of gonadotropin excretion.
The use of flutamide is contraindicated in severe diseases of the liver, kidneys, thyroid gland.
Release form: tablets (light yellow color) on 0,25 g.
Storage: at room temperature.
Nilutamide is similar in structure and effect to niftholid, a non-steroidal antiandrogen. (Nilutamide; synonym for anandrone - Anandron) - 5, 5-dimethyl-3- [4-nitro-3- (trifluoromethyl) phenyl] -2, 4-imidazolidinedione.