Description of the medicine: Triombrastum 60% and 76% for injection (Triombrastum 60% et 76% pro injectionibus)
TRIOMBRAST 60% and 76% FOR INJECTION (Triombrastum 60% et 76% pro injectionibus).
Triombrast (acid) is a triiodo-containing drug.
Triombrast for injection is an aqueous solution containing a mixture of sodium and methyl glucamine triombrast salts (3, 5-diacetylamino-2, 4, 6, triiodobenzoic acid) in a ratio of 1: 6, 6. Similar foreign drugs are available under the names: Verografin, Urografin, Urotrastin .
The sodium salt of 3, 5 diacetylamino -2, 4, 6 - triiodobenzoic acid was previously produced as an X-ray contrast agent called "triombrin."
Methylglucamine salt of this acid is sold abroad under the name Perografin.
Transparent colorless or light yellow liquid; pH 6, 5 - 7, 7; 1 ml of a 60% solution contains 292 mg of iodine, 1 ml of a 76% solution contains 370 mg of iodine.
Used for x-ray examination of blood vessels and the heart (angiocardiography; aortography, arteriography, selective angiography, etc.), kidneys, urinary tract.
The drug is rapidly excreted from the body by the kidneys.
Depending on the indications, triombrast is administered intravenously or in the cavity (in the bladder, renal pelvis).
Before using the drug, the patient's individual sensitivity to iodine is examined, for which, on the eve of use, triombrast is introduced into the vein (very slowly) in an amount of not more than 1 ml (taking into account the patient's age). In case of hypersensitivity (the appearance of itching; urticaria, runny nose, edema, general malaise, tachycardia, respiratory failure, cyanosis, etc.), the use of the drug is contraindicated.
When angiocardiography, up to 60 ml of a 76% triombrast solution are used (10-30 ml per second are injected); when aortography is injected into the aorta 30-60 ml of a 76% solution of the drug (10-30 ml / s); with peripheral arteriography, a 60% solution of the drug is administered intraarterially in the upper limb in an amount of 10 - 20 ml, in the lower limb - 20 - 40 ml (8 - 12 ml / s); when phlebography is used intravenously - on the upper limb 10 - 20 ml of a 60% solution of triombrast, on the lower limb - 20 - 40 ml (3 - 5 ml / s); with splenoportography, 50 ml of a 76% solution of the drug (8 ml / s) is injected into the spleen Z0.
In the study of the urinary tract used for excretory urography 20 ml of 60% triombrast (0.3 ml / s); 40-60 ml of 60% or 76% solution (0.3 ml / s) are sometimes administered intravenously to adults.
For infusion urography, a mixture of 80 ml of 60% and 76% triombrast solutions with 80 ml of 5% glucose solution (20-30 drops per minute) is injected into a vein.
For retrograde pyelography and cystography, triombrast is diluted with isotonic sodium chloride solution or 5% glucose solution to a 30% solution. For pyelography, a solution (usually 3–8 ml) is injected through a catheter into the urinary tract under slight pressure under visual x-ray control; For cystography, 100-200 ml of the solution is injected into the bladder.
With the introduction of triombrast, a sensation of fever, dizziness, nausea, vomiting, increased heart rate, and cyanosis are possible.