Description of the medicine: Propofol (Propofol)

Propofol.

2,6-Diisopropylphenol.

Synonyms: Diprivan, Pofol, Recofol, Diprivan, Pofol, Recofol.

Easily soluble in water, forming a white oily emulsion.

A relatively new (1980s) remedy for short-acting intravenous anesthesia. Anesthesia develops in 20-45 seconds and continues after a single injection of 30-60 seconds.

Analgesic effect does not.

Applied for induction of anesthesia and maintenance of general anesthesia, as well as for short-term surgical and diagnostic interventions.

Adults take 0.02-0.04 g (20-40 mg) every 10 seconds (until the necessary degree of anesthesia is developed); Children over the age of 8 years - at a rate of 2.5 mg / kg. To maintain anesthesia, drip infusion or repeated bolus administration is used. The dose is set individually (usually at a rate of 4-12 mg / kg per hour). At short-term manipulations enter at the rate of 0.5-1 mg / kg for 1-5 minutes, maintenance of sedation is provided by infusion at a rate of 1.5-4.5 mg / kg per hour.

The use of the drug may be accompanied by the occurrence of arterial hypotension, bradycardia, short-term apnea and (rarely) seizures, opisthotonus, pulmonary edema; Nausea, vomiting and headache, fever are possible upon awakening.

The drug should be used with caution in epilepsy, violations of lipid metabolism, diseases of the cardiovascular system, respiratory system, liver, kidneys, anemia.

It is not recommended to use in obstetric practice (the drug penetrates the placental barrier).

Product: 1% aqueous (isotonic) emulsion in 20 ml ampoules, 20, 50 and 100 ml vials and 50 ml syringes (after opening ampoules and vials the drug should be used within 6 hours).

Storage: at a temperature of 2 to 25 ° C; Do not allow freezing.