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Description of the medicine: Propofol (Propofol)

PROPOFOL (Propofol).


Synonyms: Diprivan, Pofol, Rekofol, Diprivan, Pofol, Recofol.

Easily soluble in water, forming a white oily emulsion.

A relatively new (1980s) drug for short-term intravenous anesthesia. Anesthesia develops after 20-45 s and continues after a single injection of 30-60 s.

It does not have an analgesic effect.

It is used for induction of anesthesia and maintenance of general anesthesia, as well as for short-term surgical and diagnostic interventions.

Adults are administered 0.02-0.04 g (20-40 mg) every 10 s (until the development of the necessary degree of anesthesia); children over the age of 8 years - at the rate of 2.5 mg / kg. To maintain anesthesia, drip infusion or repeated bolus administration is used. The dose is set individually (usually at the rate of 4-12 mg / kg per hour). For short-term manipulations, they are administered at a rate of 0.5-1 mg / kg for 1-5 minutes, the sedation is maintained by infusion at a rate of 1.5-4.5 mg / kg per hour.

The use of the drug may be accompanied by the occurrence of arterial hypotension, bradycardia, short-term apnea and (rarely) seizures, opisthotonus, pulmonary edema; upon awakening, nausea, vomiting and headache, fever are possible.

The drug should be used with caution in epilepsy, lipid metabolism disorders, diseases of the cardiovascular system, respiratory system, liver, kidney, anemia.

It is not recommended for use in obstetric practice (the drug crosses the placental barrier).

Release form: 1% aqueous (isotonic) emulsion in ampoules of 20 ml, vials of 20.50 and 100 ml and syringes of 50 ml (after opening the ampoules and vials, the drug should be used within 6 hours).

Storage: at a temperature of 2 to 25C; no freezing allowed.