Description of the medicine: Lamotrigine (Lamotrigine)

LAMOTRIGINE (Lamotrigine).

3,5-Diamino-6- (2,3-dichlorophenyl) -1,2,4-triazine.

Synonyms: Lamyctal, Lamictal.

Original in structure and action anticonvulsant (antiepileptic) drug.

Anticonvulsant action is associated with the stabilization of presynaptic neuronal membranes, the blockade of potential-dependent sodium channels and the prevention of the release of excitatory neurotransmitter amino acids (mainly glutamate, as well as aspartate).

When ingested, the drug is well absorbed, C max is 2-2.5 h; T 1/2 - 30 hours; Metabolized in the liver with the formation of glucoronides; Is excreted mainly by urine, in small amounts by feces.

Applied for monotherapy and additional therapy of partial and generalized seizures of epilepsy. Effective in cases of resistance to other antiepileptic drugs.

Assign adults and children over 12 years with monotherapy, starting at a dose of 0.025 g (25 mg) 1 time per day for 2 weeks, then increase the dose to 0.05 g once daily for the next 2 weeks, then gradually increase the dose to 0.05-0.1 g every 1-2 weeks until a therapeutic effect is obtained. The average maintenance dose of 0.2 g per day in 2 divided doses (in some cases up to 0.5 g per day).

Children aged 2 to 12 years are prescribed from 0.2 mg / kg once a day for 2 weeks, then 0.5 mg / kg once a day for 2 weeks, then select an effective therapeutic dose. The average maintenance dose is 1-5 mg / kg per day in 1-2 divided doses.

Lamotrigine is used in combination with other antiepileptic drugs. It is, however, necessary to take into account that phenobarbital, carbamazepine, hexamidine (in connection with induction of liver metabolizing enzymes) can weaken its effect, and sodium valproate slows lamotrigine metabolism and enhances its effect. Therefore, with the simultaneous administration of sodium valproanum, the dose of lamotrigine is reduced: the initial daily (in the first 2 weeks) to 0.05 g, and the maintenance dose to 0.2-0.4 g.

The drug is usually well tolerated; May be observed, however, dizziness, headache, drowsiness or increased irritability, diplopia, allergic reactions (skin rash, Quincke's edema).

Contraindicated in liver failure.

Caution is required when prescribing lamotrigine to elderly people and pregnant women; In the absence of emergency in the first 3 months of pregnancy, the drug should not be taken. It is not recommended to prescribe lamotrigine for children under 2 years of age.

Product: tablets of 0.025; 0,05 and 0,1 g (25, 50 and 100 mg), chewing tablets - 0,005; 0.025 and 0.1 g (N.30).

Storage: List B.