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Description medications: Granisetron (Granisetron)

Granisetron (Granisetron).

1-Methyl-N- (9-methyl-endo-9-azabicyclo [3.3.1] non-3-yl) -1H-indazole-3-carboxamide.

Synonym: Kytril, Kytril.

White powder. Soluble in water.

The structure has similarities with tropindolom (tropisetron).

By the action is, like ondansetron (cm.) And tropindolu (cm.), An antiemetic, a blocker of serotonin 5-HT3 receptor.

If ingestion is well absorbed in the gastrointestinal tract; biotransformation in the liver, bile appears mainly.

It is used to prevent and treat nausea and vomiting associated with cytotoxic drugs and therapy in the postoperative period.

Assign inside and intravenously.

Inside designate adults and children over 12 years of 0,001 grams (1 mg), 2 times a day during cytostatic therapy. The first dose is taken not earlier than 1 hour before the start of the use of cytotoxic drugs. The maximum daily dose - not more than 0.009 g (9 mg).

For intravenous administration, the contents of one vial (3 mg) were diluted in 20-50 ml of sterile 0.9% sodium chloride or 5% glucose solution, or 10% mannitol solution and injected within 5 min. For the prevention of nausea and vomiting is applied 1 time a day (in some cases 2-3 times) for 5 days. Introduction finish before starting treatment with cytostatics. For therapeutic purposes, the drug is used in the same doses as for prevention. If necessary, additional infusion is performed at intervals of not less than 10 minutes. The maximum daily dose of 0.009 g (9 mg) (three infusions of 3 mg). Babies are administered (i.v.) of 0.04 mg / kg (to 3 mg) once (10-30 ml infusion solution) for 5 min.

In applying the drug may be headache, allergic reactions, constipation, elevated liver transaminases.

Not recommended to prescribe during pregnancy and breastfeeding.

Do not mix granisetron solutions with solutions of other drugs. A solution of granisetron is recommended to prepare ex tempore (stored at room temperature not exceeding 24 hours in a cool, dark place).

Method of issuance: pills to 0,001 grams (1 mg) (10 N. The); 0.1% concentrate for infusion in vials of 3 ml (N. 5).

Storage: List B.