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Description medications: Doxepin (Doxepine)

Doxepin (Doxepine).

3-Dibenz [b, e] oxepin-11 (6H) -ylidene-N, N-dimethyl-1-propanamine hydrochloride.

Synonym: Sinekvan, Sinequan.

The white crystalline powder. It is soluble in water, worse - in alcohol and chloroform.

Antidepressant with anxiolytic and sedative properties. It has antiserotoninovym, holinoliticheskim, protivogistaminnym and protivoyazvenyym action.

Quickly and completely absorbed in the digestive tract, T1 / 2 is 28-52 hours; pobvergaetsya biotransformation in the liver with the formation of the active metabolite dimetildoksepina, excreted by the kidneys.

Apply with depressive and neurotic states, alcoholism with anxiety and restlessness; in therapeutic practice - with duodenal ulcer.

Assign inside. The initial daily dose for adults 0.075 g (75 mg) in 3.1 reception, if necessary, it can be increased to 0.3 g per day, administered for elderly 0.03-0.05 g (30-50 mg) per day , children - 0.5 mg / kg per day. The therapeutic effect is usually 2-3 weeks after starting treatment.

Possible side effects: neuralgia, urinary retention, blurred vision, drowsiness, hallucinations, ataxia, extrapyramidal disorder, hypotension, allergic reactions, etc.

The drug is contraindicated in atrioventricular block, angle-closure glaucoma, prostatic hypertrophy.

Long-term treatment is not recommended sudden cessation of its activities because of the risk of withdrawal symptoms; should refrain from activities requiring increased rate of mental and physical reactions.

Do not appoint doxepin simultaneously with MAO inhibitors; the period of treatment is not allowed alcohol.

Product: capsules and 0.025 to 0.01 g (10 and 20 mg) (N. 15,30).

Storage: List B.