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Description medications: Aphrodine

Yohimbine (Yohimbine).

Methyl gidroksiiohimban-17A-16A-carboxylic acid.

Available in the form of hydrochloride.

Synonyms: Aphrodine, Iohimbina, Quebrachin, Yohimvetol .

Alkaloid isolated for the first time in 1896 from the bark of a West African tree Corynanthus yohimbine (Yambehou) -Pausinystalia yohymbe, and v1950 city - from Rauwolfia roots.

Considered as indolylalkylamines derivative having similarities with reserpine.

Is selective competitive antagonist of the A2-adrenergic receptors (antagonist of clonidine, clonidine). It activates the adrenergic processes in the central nervous system, increases heart rate, increases motor activity, causing tremors. It has a mild stimulating effect on the spinal cord reflexes.

It has long been suggested as a means of stimulating sexual activity (based on the fact that the infusion of the bark of the tree Yambehou natives have used for this purpose). Experimental and clinical studies of this, however, is not confirmed. Nevertheless, in the late 1980s. yohimbine again offered for use in neurodegenerative disorders of erection, as well as male menopause.

Quickly and completely absorbed in the gastrointestinal tract, with max of 1.3 h, T1 / 2 in plasma - 40 minutes, easily penetrates the central nervous system; It is metabolized in the liver.

Assign into tablets as 0.005-0.01 g (10.5 mg), 1-3 times a day for 3-10 months. If necessary, repeat the course (with a 10-week intervals).

Apply yohimbine (as well as other "afrodizika") should be on prescription and under supervision of a physician.

Possible side effects: agitation, tremor, headache, tachycardia, hypotension.

The drug is contraindicated in patients with arterial hypotension and renal dysfunction.

Product: pills to 0,005 grams (5 mg) (N. The 20, 100).