Description of the medicine: Yohimbine (Yohimbine)

Yohimbine.

Methyl 17A-hydroxyiodimine-16A-carboxylic acid ester.

Produced in the form of hydrochloride.

Synonyms: Aphrodine, Iohimbina, Quebrachin, Yohimvetol.

The alkaloid, isolated for the first time in 1896 from the bark of the West African tree Corynanthus yohimbine (Yambehou) -Pausinystalia yohymbe, and in 1950 - from the roots of Rauwolfia.

It is considered as an indolylalkylamine derivative having elements of resemblance to reserpine.

It is an selective competitive antagonist of A2-adrenoreceptors (clonidine-clonidine antagonist). Activates adrenergic processes in the central nervous system, increases the heart rate, increases motor activity, causes tremor. Has a moderate stimulating effect on spinal cord reflexes.

It has long been suggested as a means of stimulating sexual activity (on the basis that the bark of Yambehou tree bark was used by the natives for this purpose). This, however, has not been confirmed by experimental and clinical studies. Nevertheless, in the late 1980s. Yohimbine again suggested for use in neurogenic erectile dysfunction, as well as menopause menopause.

Quickly and completely absorbed in the digestive tract, Cmax is 1.3 h, T1 / 2 in plasma - 40 min, easily penetrates into the central nervous system; Is metabolized in the liver.

Assign inside as tablets to 0,005-0,01 g (5-10 mg) 1-3 times a day for 3-10 months. If necessary, repeat the course (with an interval of 10 weeks).

Apply yohimbine (as well as other "aphrodisiacs") follows the intended use and under the supervision of a physician.

Possible side effects: agitation, tremor, headache, tachycardia, arterial hypotension.

The drug is contraindicated in arterial hypotension and impaired renal function.

Form release: tablets of 0.005 g (5 mg) (N. 20, 100).