Before taking the course, consult a doctor!
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Description of the medicine: Mirtazapine
Mirtazapine.
1,2,3,4,10,14-Hexahydro-2-methylpyrazino [2,1-a] pyrido [2,3-c] benzazepine.
Synonym: Remeron, Remeron.
White crystalline powder from white to cream color. Slightly soluble in water.
It refers to "balanced" antidepressants with predominance of anxiolytic and sedative action.
Has a special mechanism of action - selectively blocks central presynaptic A2-adrenoreceptors and postsynaptic 5-HT2- and 5-HT3-serotonin receptors, which improves adrenergic and serotonergic transmission.
In addition, it is an active blocker of H1-histamine and moderately active - m-cholinergic receptors.
After oral administration quickly and completely absorbed, bioavailability is 50%, Cmax - 2 h, T1 / 2 - 24-37 h; Is excreted mainly with urine.
Applied with endogenous depressions of various etiologies. Assign inside adults to 0,03-0,045 g (30-45 mg) 1 time per day (at night). Clinical effect usually develops after 1-2 weeks. Duration of treatment up to 6 months.
With the use of the drug, a number of side effects are possible: sedation, extrapyramidal disorders, myoclonus, paresthesia, dystonia, migraine, arrhythmias, oppression of hematopoiesis, jaundice, urinary retention, myasthenia gravis, accommodation disorder, allergic reactions,
The drug is contraindicated in renal and hepatic insufficiency, infectious and cardiovascular diseases, pregnancy, breast-feeding.
Incompatible with MAO inhibitors.
The form of release: tablets on 0,015; 0.03 and 0.045 g (15, 30 and 45 mg) (N. 10, 30).
Storage: List B.
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