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Description of the medicine: Pramipexole

PRAMIPEXOL (Pramipexole).

(S) -2-Amino-4,5,6,7-tetrahydro-6- (propylamino) -benzothiazole.

Synonym: Mirapex, Mirapex.

It is a stimulator of D2-dopamine receptors of the striatum.

Quickly and completely absorbed in the digestive tract, bioavailability is 90%, Cmax - 2 h, T1 / 2 - 8-12 h; Is excreted by the kidneys in an unchanged form.

Applied with Parkinson's disease (with monotherapy and in combination with drugs of levodopa at all stages of the disease).

Assign inside, starting at a dose of 0.375 mg per day (in 3 divided doses), if necessary, it can be increased every 5-7 days according to the scheme: on the 1st day at 0.375 mg and from the 2nd to the 7th day on 0 , 75 mg per day, maintaining a dose of 1.5-4.5 mg per day.

When combined with levodopa, doses of pramipexole are reduced.

They abolish pramipexole gradually (for at least 1 week) because of the danger of malignant neuroleptic syndrome.

Possible side effects: orthostatic hypotension, asthenia, dyskinesia, akathisia, drowsiness or insomnia, hallucinations, dyspepsia; Rarely - dysuria, a violation of accommodation, myasthenia gravis and peripheral edema.

Be wary appoint with arterial hypotension, dyskinesia associated with taking levodopa, patients with renal insufficiency (doses are reduced several times), as well as patients engaged in activities that require increased attention.

The appointment during pregnancy is possible only for life indications.

Dopamine antagonists (neuroleptics, metoclopramide) reduce the effectiveness of pramipexole.

Product: tablets of 0.000125; 0.00025; 0.001 and 0.0015 g (0.125, 0.25, 1 and 1.5 mg) (N. 10, 30).

Storage: List B.