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Description of the medicine: Rofecoxib (Rofecoxib)


4- [4- (Methylsulfonyl) phenyl] -3-phenylfuran-2 (5H) -one.

Synonym: Viox, Viox.

Has anti-inflammatory and analgesic effect.

Bioavailability is 90%, Cmax is 2-3 hours, T1 / 2 is 17 hours; Undergoes biotransformation in the liver, is secreted mainly by the kidneys in the form of metabolites.

Applied with osteoarthritis and acute pain syndrome (dysmenorrhea, with dental and orthopedic operations).

Assign inside of 0.0125-0.05 g (12.5-50 mg) 1 time per day.

Possible side effects: dyspepsia, bronchitis, drowsiness, hallucinations, increased blood pressure, rarely - ulcerogenic effect, peripheral edema, asthenia.

Method of production: tablets of 0.0125 and 0.025 g (12.5 and 25 mg) (N. 7, 14); 0.25% and 0.5% suspension for oral administration in 150 ml vials.

Storage: List B.