Description of the medicine: Sertraline (Sertraline)
(1S, 4S) -4- (3,4-dichlorophenyl) -1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride.
Synonym: Zoloft, Zoloft.
White crystalline powder. Slightly soluble in water and isopropyl alcohol, soluble in ethanol.
Relate to the "balanced" antidepressants with a predominance of anxiolytic properties.
Active selective serotonin reuptake inhibitor; weakly affects the reuptake of norepinephrine and dopamine. It does not have a specific affinity for adrenergic, m-cholinergic, GABAergic, dopaminergic, histaminergic, benzodiazepine, as well as serotonergic receptors. It does not inhibit MAO activity.
When taken orally, the drug is rapidly and completely absorbed, Cmax is 4-8 hours; undergoes biotransformation in the liver with the formation of the active metabolite of N-desmethylsertraline, T1 / 2 of sertraline and the active metabolite, respectively 26 and 62-104 hours; a stable plasma concentration is established approximately 7 days after the start of administration (in the elderly after 2-3 weeks); excreted in the urine (mainly in the form of metabolites) and with feces.
Used mainly for the treatment of severe depressive conditions.
Assign inside. The usual adult dose is 0.05 g (50 mg) per day (a single dose in the morning or in the evening, regardless of food intake), if necessary and well tolerated, it is gradually increased by 0.05 g at intervals of 1 week. The maximum daily dose for adults is 0.2 g (200 mg). For children, the initial dose of 0.025 g (25 mg) per day, if necessary, it can be increased after 1 week to 0.05 g (50 mg) per day.
The maximum daily dose for children is 0.2 g.
The onset of the drug is usually observed after 2-4 weeks.
Sertraline is generally well tolerated. Due to the lack of anticholinergic action does not cause atony of the intestine, bladder. Drowsiness, hyperkinesis, tachycardia, edema, bronchospasm, cough, arthralgia, as well as allergic skin reactions can be observed.
The drug is contraindicated in breastfeeding and in childhood.
Sertraline should not be taken simultaneously with MAO inhibitors, tricyclic antidepressants, tranquilizers, sulfonylureas, coumarin anticoagulants, and dinoxin. When taking the drug, alcohol is not allowed.
Care must be taken when prescribing the drug to people whose work requires increased attention.
Release form: tablets on 0,05 and 0,01 g (50 and 100 mg) (N. 14, 28).
Storage: List B.