Description of the medicine: Sertraline

CERTRALINE (Sertraline).

(1S, 4S) -4- (3,4-dichlorophenyl) -1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride.

Synonym: Zoloft, Zoloft.

White crystalline powder. Poorly soluble in water and isopropyl alcohol, soluble in ethanol.

They are referred to "balanced" antidepressants with predominance of anxiolytic properties.

Active selective inhibitor of reverse neuronal seizure of serotonin; Slightly affects the re-uptake of norepinephrine and dopamine. Specific affinity for adrenergic, m-cholinergic, GABAergic, dopaminergic, histaminergic, benzodiazepine, and serotonergic receptors does not. Does not have an inhibitory effect on MAO activity.

When ingested, the drug is quickly and completely absorbed, C max is 4-8 h; Undergoes biotransformation in the liver with the formation of an active metabolite of N-desmethylsertralin, T1 / 2 sertraline and active metabolite - 26 and 62-104 hours, respectively; A stable concentration in the blood plasma is established approximately 7 days after the initiation of admission (in elderly people 2-3 weeks later); Is excreted from the body with urine (mainly in the form of metabolites) and with feces.

Applied mainly for the treatment of severe depressive conditions.

Assign inside. The usual dose for adults is 0.05 g (50 mg) per day (single intake in the morning or evening, regardless of food intake), if necessary and well tolerated, gradually increase by 0.05 g at intervals of 1 week. The maximum daily intake for adults is 0.2 g (200 mg). For children, the initial dose of 0.025 g (25 mg) per day, if necessary, it can be increased after 1 week to 0.05 g (50 mg) per day.
The maximum daily intake for children is 0.2 g.

The beginning of the drug is usually seen in 2-4 weeks.

Sertraline, as a rule, is well tolerated. In connection with the lack of anticholinergic action does not cause atony of the intestine, bladder. There may be drowsiness, hyperkinesia, tachycardia, edema, bronchospasm, cough, arthralgia, as well as skin allergic reactions.

The drug is contraindicated for breastfeeding and in childhood.

Do not take sertraline simultaneously with MAO inhibitors, tricyclic antidepressants, tranquilizers, sulfonylurea derivatives, coumarin anticoagulants, dinoxin. When taking the drug is not allowed to drink alcohol.

Care must be taken when prescribing the drug to people whose work requires increased attention.

Form release: tablets of 0.05 and 0.01 g (50 and 100 mg) (N. 14, 28).

Storage: List B.