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Description of the medicine: Sildenafil citrate (Sildenafil citrate)

Sildenafil citrate.

Citrate 1 - [[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-A] pyrimidin-5-yl) 4-ethoxyphenyl] sulfonyl] piperazine.

Synonym: Viagra, Viagra.

Initially, it was suggested as a cardiovascular agent, but it was not effective enough; At the same time, some male patients who received it noted an increase in sexual potency; The drug was studied in this direction, the data were confirmed and sildenafil (called "Viagra") received medical treatment.

The mechanism of action is still not clear enough. From the point of view of biochemistry, the main emphasis now is on the ability of sildenafil to selectively inhibit the activity of the type V phosphodiesterase enzyme that inactivates cyclic guanosine monophosphate (c-HMF) involved in relaxing the smooth muscles of the cavernous body and improving blood supply to the penis. Sildenafil does not have a direct relaxing effect on the vessels of the cavernous body, but it enhances the vasodilating effect of the nitric oxide (NO) released during sexual stimulation with respect to this tissue. It is obvious that the role of spinal cord stimulation plays a physiological role, especially in the light of data on the effectiveness of the drug in cases of potency disorders associated with spinal cord lesions.

When ingested quickly and completely absorbed, bioavailability is 40%, Cmax - 60 min, T1 / 2 - 4 hours; Is subjected to intensive biotransformation in the liver with the formation of an active metabolite, is excreted mainly with feces in the form of metabolites.

Assign inside (in the form of tablets), usually at a dose of 0.05 g (50 mg) for 1 hour before sexual intercourse. Depending on the effect, the dose can be reduced to 0.025 g or increased to 0.1 g. The maximum recommended dose is 0.1 g once a day.

According to available data, the drug is usually well tolerated. Possible side effects: headache, dizziness, dyspepsia, widening of peripheral vessels (tides), violation of light and color perception, clear vision, arthralgia and myalgia.

The drug is contraindicated in severe somatic diseases.

Cardiologists pay attention to the dangers of using the drug by patients who use nitrates (that is, a wide range of patients with IHD). In the information materials of recent times, the intake of nitrates refers to contraindications for the appointment of Viagra. Endocrinologists recommend that patients with diabetes consult a cardiologist and ophthalmologist. In general, it is advisable to use the drug on the advice of a doctor.

Product: tablets of 0.025; 0.05 and 0.1 g (25, 50 and 100 mg) (N. 1, 4, 8, 12).