Description of the medicine: Sultopride (Sultopride)

SULTOPRID (Sultopride).

N - [(1-Ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide.

Synonyms: Barnetil, Topral, Barnetil, Topral.

By chemical structure and action is close to sulpiride. Instead of an amino group (with a sulfonyl group) contains an ethyl radical.

Has antipsychotic, sedative and analgesic effects.

Neuroleptic effect is associated with blockade of D2-dopamine receptors in the brain. It shows moderate antiserotonin and cathleptogenic activity.

After intake, absorbed quickly and completely, the bioavailability is 80-90%, Cmax - 0.5-2h, T1 / 2 - 3-5 hours, excreted by the kidneys in an unchanged form.

Apply for psychosis and chronic alcoholism for treatment and arresting aggression and arousal.

Assign inside and intramuscularly.

Inside appoint 0.4 to 1.6 grams per day (1-4 times a day), with the improvement of the state reduce the dose to 0.4-0.6 g per day.

With manic states and for stopping excitation, intramuscularly inject 0.4-1.2 g per day (maximum daily dose of 1.6 g).

The drug is used only in the hospital.

Possible side effects: extrapyramidal disorders, loss of appetite, diarrhea, drowsiness, bradycardia, orthostatic hypotension, hyperprolactinaemia, galactorrhea, amenorrhea, gynecomastia, impotence, with prolonged use of high doses - depression, convulsive syndrome.

The drug is contraindicated in bradycardia, pheochromocytoma, hypokalemia.

Care should be taken with epilepsy, parkinsonism, severe cardiovascular diseases.

Strengthens the depressing effects of narcotic analgesics, barbiturates, tranquilizers, alcohol, antitussives and weakens - levodopa. Side effects of sultopride aggravate tricyclic antidepressants, phenothiazine drugs, antihypertensives (including B-blockers and clonidine), cardiac glycosides and antiarrhythmics drugs I and III Classes, hypokalemia.

Forms of release: tablets of 0.4 g (N. 10, 20, 100); 10% solution for injection in ampoules of 2 ml.