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Description of the medicine: Sultopride (Sultopride)

SULTOPride (Sultopride).

N - [(- 1-Ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide.

Synonyms: Barnetil, Topral, Barnetil, Topral.

The chemical structure and action is close to sulpiride. Instead of an amino group (with a sulfonyl group) it contains an ethyl radical.

It has antipsychotic, sedative and analgesic effects.

The antipsychotic effect is associated with blockade of the D2 dopamine receptors of the brain. It exhibits moderate antiserotonin and catoleptogenic activity.

After oral administration, it is absorbed quickly and completely, bioavailability is 80-90%, Cmax - 0.5-2 hours, T1 / 2 - 3-5 hours, excreted by the kidneys unchanged.

Used for psychosis and chronic alcoholism for the treatment and relief of aggressiveness and arousal.

Assign inside and intramuscularly.

Inside, from 0.4 to 1.6 g per day is prescribed (1-4 times a day), with improvement, the dose is reduced to 0.4-0.6 g per day.

In manic conditions and for stopping excitation, they are administered intramuscularly at 0.4-1.2 g per day (maximum daily dose of 1.6 g).

The drug is used only in a hospital.

Possible side effects: extrapyramidal disorders, loss of appetite, diarrhea, drowsiness, bradycardia, orthostatic hypotension, hyperprolactinemia, galactorrhea, amenorrhea, gynecomastia, impotence, with prolonged use of high doses - depression, convulsive syndrome.

The drug is contraindicated in bradycardia, pheochromocytoma, hypokalemia.

Caution should be exercised in epilepsy, parkinsonism, and severe cardiovascular diseases.

It enhances the depriving effects of narcotic analgesics, barbiturates, tranquilizers, alcohol, antitussive drugs and weakens levodopa. Side effects of suloprid exacerbate tricyclic antidepressants, phenothiazine drugs, antihypertensive drugs (including B-adrenergic blocking agents and clonidin and antagonists III and clonidin) classes, hypokalemia.

Method of release: tablets of 0.4 g (N. 10, 20, 100); 10% solution for injection in ampoules of 2 ml.