Medication Description: Sultopride (Sultopride)
N - [(- 1-Ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide.
Synonyms: Barnetil, Topral, Barnetil, Topral.
The chemical structure and action is close to sulpiride. Instead of an amino group (with a sulfonyl group) it contains an ethyl radical.
It has antipsychotic, sedative and analgesic effects.
The neuroleptic effect is associated with blockade of the D2-dopamine receptors in the brain. It exhibits moderate antiserotonin and catholic activity.
After ingestion is absorbed quickly and completely, bioavailability is 80-90%, Cmax - 0.5-2h, T1 / 2 - 3-5h, excreted by the kidneys in unchanged form.
Applied with psychosis and chronic alcoholism for the treatment and relief of aggressiveness and arousal.
Assign inside and intramuscularly.
Inside prescribed from 0.4 to 1.6 g per day (1-4 times per day), while improving the state, reduce the dose to 0.4-0.6 g per day.
In manic states and for relief of arousal, intramuscular injection of 0.4-1.2 g per day (maximum daily dose of 1.6 g) is administered.
The drug is used only in the hospital.
Possible side effects: extrapyramidal disorders, loss of appetite, diarrhea, drowsiness, bradycardia, orthostatic hypotension, hyperprolactinemia, galactorrhea, amenorrhea, gynecomastia, impotence, with prolonged use of high doses - depression, convulsive syndrome.
The drug is contraindicated in bradycardia, pheochromocytoma, hypokalemia.
Care should be taken in epilepsy, parkinsonism, severe cardiovascular diseases.
Deprimiruyuschie Enhances effects of narcotic analgesics, barbiturates, tranquilizers, alcohol, antitussives and weakens - levodopa.Pobochnye effects sultopride exacerbate tricyclic antidepressants, phenothiazine drugs, antihypertensive agents (including B-blockers and clonidine), cardiac glycosides, antiarrhythmic drugs, and I and III grades, hypokalemia.
Method of production: tablets of 0.4 g (N. 10, 20, 100); 10% solution for injection in 2 ml ampoules.