Description of the medicine: Cisapride

Cisapride.

Cis-4-Amino-5-chloro-N- [1- [3- (p-fluorophenoxy) propyl] -3-methoxy-4-piperidyl] -ortho-anisamide.

Synonyms: Coordinate, Periperid, Peristyle, Sisapro, Tsisap, Cisapid, Cisapride, Cisap, Cisapid, Cisapro, Coordinax, Peristil, Prepulsid.

Crystalline powder. Insoluble in water, poorly soluble in methanol, soluble in acetone.

Cholinomimetic substance, differing in structure from acetylcholine-like compounds.

The mechanism of action is associated with increased release of acetylcholine from the endings of postganglionic cholinergic nerves, especially the mesenteric plexus of the intestine. Increases the tone and motor activity of the intestine, as well as the tone of the sphincter of the esophagus, prevents the throwing of stomach contents into the esophagus. Accelerates the emptying of the stomach and duodenum.

The effect of cisapride is close to metoclopramide (see) and domperidone (see), however, according to the molecular mechanisms of action, these preparations differ significantly: cisapride is a stimulant of cholinergic processes, and metoclopramide and domperidone are antagonists of dopamine (D2) receptors.

Acts faster and stronger than metoclopramide and domperidone.

Quickly absorbed in the digestive tract, bioavailability is 35-40%, Cmax - 1-1.5 h, T1 / 2 (with oral administration) - 6-12 h; Undergoes biotransformation in the liver, is excreted in urine and feces in the form of metabolites.

Assign for paresis of the stomach, reflux-esophagitis, atony of the intestine (chronic constipation), dyspepsia, to accelerate peristalsis during radiographic examination of the gastrointestinal tract.

Apply inside and parenteral.

Inside (15 minutes before meals), adults are prescribed in the form of tablets 0,005-0,015 g (up to 0,02 g) or 10 ml 0.1% suspension 3-4 times a day.

"Standards of diagnosis and treatment of patients with diseases of the digestive system" recommend the use of cisapride in the complex therapy of postcholecystectomy syndrome and cholecystitis (0.01 g 3-4 times a day for 2 weeks or more).

Children are prescribed in the form of a suspension: at the age of 1 year to 5 years, 0.0025 grams (2.5 mg), the oldest by 0.005-0.01 g (5-10 mg) 2-3 times a day.

Possible side effects: drowsiness, convulsions, arrhythmias, xerostomia, dyspepsia, hepatitis, myalgia, edema, oppression of hematopoiesis, allergic reactions.

Contraindications: gastrointestinal bleeding, expressed violations of the liver and kidneys, pregnancy, breast-feeding.

Forms of release: tablets of 0.005 and 0.01 g (5 and 10 mg) (N. 20, 30); 0.1% suspension for oral administration in vials of 60 and 100 ml; 0.2% and 0.5% solutions for injection in ampoules of 2 ml.

Storage: List B.